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Barbara D. Abbott
Researcher at Research Triangle Park
Publications - 79
Citations - 6142
Barbara D. Abbott is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Developmental toxicity & Receptor. The author has an hindex of 40, co-authored 79 publications receiving 5600 citations. Previous affiliations of Barbara D. Abbott include United States Environmental Protection Agency.
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Journal ArticleDOI
Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures.
Cynthia J. Wolf,Suzanne E. Fenton,Judith E. Schmid,Antonia M. Calafat,Zsuzsanna Kuklenyik,Xavier A. Bryant,Julie R. Thibodeaux,Kaberi P. Das,Sally S. White,Christopher Lau,Barbara D. Abbott +10 more
TL;DR: The postnatal developmental effects of PFOA are due to gestational exposure and exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period.
Journal ArticleDOI
Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR
Mitchell B. Rosen,Janice S. Lee,Hongzu Ren,Beena Vallanat,Jie Liu,Michael P. Waalkes,Barbara D. Abbott,Christopher Lau,J. Christopher Corton +8 more
TL;DR: It is indicated that PFOA alters most genes in wild-type mouse liver through PPARalpha, but that a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha-null mouse.
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Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis
Kaberi P. Das,Carmen R. Wood,Mimi T. Lin,Anatoly A. Starkov,Christopher Lau,Kendall B. Wallace,J. Christopher Corton,Barbara D. Abbott +7 more
TL;DR: Results indicate that most of the PFAAs increase liver TG load and promote steatosis in mice, bolstering the hypothesis that the balance of fatty acid accumulation/synthesis and oxidation is disrupted to favor accumulation.
Journal ArticleDOI
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.
Mitchell B. Rosen,Kaberi P. Das,John P. Rooney,Barbara D. Abbott,Christopher Lau,J. Christopher Corton +5 more
TL;DR: Predictive gene expression biomarkers showed that PFAAs activate CAR in both genotypes and cause feminization of the liver transcriptome through suppression of signal transducer and activator of transcription 5B (STAT5B).
Journal ArticleDOI
Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): further investigation of C4-C12 compounds.
TL;DR: The two studies together found increasing activity of PPARα with increasing chain length of the PFAA up to perfluorononanoic acid (C9) and lower activity with longer chain PFAAs with both mouse and human PPAR α.