B
Barbara Maciejewska
Researcher at University of Wrocław
Publications - 21
Citations - 1195
Barbara Maciejewska is an academic researcher from University of Wrocław. The author has contributed to research in topics: Lysin & Virulence. The author has an hindex of 12, co-authored 20 publications receiving 819 citations.
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Journal ArticleDOI
Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications
Zuzanna Drulis-Kawa,Grazyna Majkowska-Skrobek,Barbara Maciejewska,Anne-Sophie Delattre,Rob Lavigne +4 more
TL;DR: A review of the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents and several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects are discussed.
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Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process.
Agnieszka Latka,Barbara Maciejewska,Grazyna Majkowska-Skrobek,Yves Briers,Zuzanna Drulis-Kawa +4 more
TL;DR: The existing diversity in structural locations, variable architectures, enzymatic specificities, and evolutionary aspects of polysaccharide depolymerases and virion-associated lysins (VALs) are discussed and illustrated how these aspects can correlate with the host spectrum.
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Bacteriophages and phage-derived proteins--application approaches.
TL;DR: In this review, several issues of phage and phage-derived protein application approaches in therapy, diagnostics and biotechnology in general are discussed.
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Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?
TL;DR: This review discusses advantages and limitations of both agents concerning their specificity, mode of action, structural issues, resistance development, pharmacokinetics, product preparation, and interactions with the immune system and describes the current regulations for phage-based product application.
Journal ArticleDOI
Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy.
Grazyna Majkowska-Skrobek,Agnieszka Łątka,Rita Berisio,Barbara Maciejewska,Flavia Squeglia,Maria Romano,Rob Lavigne,Carsten Struve,Zuzanna Drulis-Kawa +8 more
TL;DR: It is found that depoKP36 was also effective against a native capsule of clinical K. pneumoniae strains, representing the K63 type, and significantly inhibited Klebsiella-induced mortality of Galleria mellonella larvae in a time-dependent manner.