Barbara Spagnolo

TL;DR: It is demonstrated that optical fibers with tapered tips can be used to illuminate either spatially restricted or large brain volumes and permit focal or broad illumination that can be precisely and dynamically matched to experimental needs.

TL;DR: In this paper, the authors exploit modal properties of tapered optical fibers (TFs) to enable light collection over an extent of up to 2'mm of tissue and multisite photometry along the taper.

TL;DR: In this paper, the authors combined static and dynamic mechanical analysis on purpose-designed microstructures (microbending of pillar-like structures and picometer-sensitive laser Doppler vibrometry of drumlike structures) to viably and nondestructively estimate Young's modulus, Poisson's ratio, and density of materials for 2P lithography.

TL;DR: 3D structural designs and materials are reviewed in the context of new experimental designs, including structures for assessing cancer cell invasiveness, and 3D architectures and materials to study stem cell differentiation, as 3D structure shape and patterning play a key role in defining cell fates.

TL;DR: The results presented in this manuscript can guide neuroscientists to design optogenetic experiments on the base of this mode-division demultiplexing approach, providing a tool that potentially allow for dynamic targeting of regions with diverse extension, from the mouse VTA up to the macaque visual cortex.