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Barry Heavey
Researcher at Research Institute of Molecular Pathology
Publications - 9
Citations - 2318
Barry Heavey is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: PAX5 Transcription Factor & Haematopoiesis. The author has an hindex of 7, co-authored 9 publications receiving 2244 citations. Previous affiliations of Barry Heavey include University of Edinburgh.
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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.
TL;DR: It is shown that pro-B cells lacking Pax5 are also incapable of in vitro B-cell differentiation unless Pax5 expression is restored by retroviral transduction, and Pax5 plays an essential role in B-lineage commitment by suppressing alternative lineage choices.
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Reversion of B Cell Commitment upon Loss of Pax5 Expression
TL;DR: Using conditional Pax5 inactivation in committed pro-B cells, it is demonstrated that Pax5 is required not only to initiate its B lymphoid transcription program, but also to maintain it in early B cell development.
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Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells
TL;DR: An unexpected and decisive role for Notch in ES cell fate determination is defined, which is likely to be a key factor in taking command of ES cell lineage choice.
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Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
TL;DR: The data indicate that Pax proteins can be converted from transcriptional activators to repressors through interaction with corepressors of the Groucho protein family.
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Transcriptional control of B-cell development
TL;DR: It is shown that negative regulatory networks play an important role in suppressing alternative gene programs and their corresponding cell fates throughout B-cell development.