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Barry M. Gumbiner
Researcher at Seattle Children's Research Institute
Publications - 124
Citations - 28975
Barry M. Gumbiner is an academic researcher from Seattle Children's Research Institute. The author has contributed to research in topics: Cadherin & Cell adhesion. The author has an hindex of 75, co-authored 117 publications receiving 27681 citations. Previous affiliations of Barry M. Gumbiner include Memorial Sloan Kettering Cancer Center & Centre national de la recherche scientifique.
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Journal ArticleDOI
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
TL;DR: A coupling between physical adhesion and developmental signaling provides a mechanism to tightly integrate physical aspects of tissue morphogenesis with cell growth and differentiation, a coordination that is essential to achieve the intricate patterns of cells in tissues.
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Regulation of cadherin-mediated adhesion in morphogenesis
TL;DR: Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis, and the dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements.
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The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation
Li Zeng,François Fagotto,Tong Zhang,Wei Hsu,Thomas J. Vasicek,William L. Perry,James J. Lee,Shirley M. Tilghman,Barry M. Gumbiner,Frank Costantini +9 more
TL;DR: Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians.
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The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.
TL;DR: The role of the epithelial adhesion molecule uvomorulin seems to mediate an early adhesion event between epithelial cells that is a prerequisite for the assembly of all elements of the junctional complex.
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Regulation of Cadherin Adhesive Activity
TL;DR: Cadherins are major cell–cell adhesion molecules involved in the development and maintenance of all solid tissues and regulation of cadherin-related interactions during tissue development and homeostasis is regulated.