Barry Mangum

TL;DR: The findings suggest that bumetanide as an add-on to phenobarbital does not improve seizure control in newborn infants who have hypoxic ischaemic encephalopathy and might increase the risk of hearing loss, highlighting the risks associated with the off-label use of drugs in newborn babies before safety assessment in controlled trials.

TL;DR: The economic return for pediatric exclusivity is variable and as an incentive to complete much-needed clinical trials in children, Pediatrics Exclusivity can generate lucrative returns or produce more modest returns on investment.

TL;DR: Normal CSF parameters do not exclude the diagnosis of neonatal Candida meningitis and the majority of infants in this cohort with CandidaMeningitis did not have evidence of candidemia at the time of diagnosis.

TL;DR: There is an urgent need to develop age- specific AEDs for preterm and term babies and these drugs must be evaluated with multicentre, collaborative trials using innovative methods and high ethical standards to overcome age-specific challenges with the ultimate aim of improving the outcome for neonates with seizures.

TL;DR: Cerebrospinal fluid parameters in infants with culture-proven Group B streptococcal meningitis in the era of intrapartum antibiotic prophylaxis are described and Hospitalized infants who undergo a lumbar puncture are frequently complicated by GBSMeningitis.