C
Catherine Chiron
Researcher at French Institute of Health and Medical Research
Publications - 227
Citations - 11293
Catherine Chiron is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Epilepsy & Dravet syndrome. The author has an hindex of 57, co-authored 221 publications receiving 10321 citations. Previous affiliations of Catherine Chiron include DePaul University & Paris Descartes University.
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Journal ArticleDOI
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial
Catherine Chiron,M.C. Marchand,A Tran,Elisabeth Rey,Philippe d'Athis,J. Vincent,Olivier Dulac,Gérard Pons +7 more
TL;DR: A controlled trial shows the antiepileptic efficacy, of add-on stiripentol in children with SMEI, and provides good reason to focus studies on a specific epilepsy syndrome.
Journal Article
Changes in regional cerebral blood flow during brain maturation in children and adolescents.
Catherine Chiron,Claude Raynaud,Bernard Maziere,Monica Zilbovicius,Louis Laflamme,Marie-Cécile Masure,Olivier Dulac,Michel H. Bourguignon,André Syrota +8 more
TL;DR: Cognitive development of the child seems to be related to changes in blood flow of the corresponding brain regions, which was studied by SPECT using 133Xe in 42 children considered as neurologically normal.
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The right brain hemisphere is dominant in human infants.
TL;DR: The development of functional brain asymmetry during childhood is confirmed by changes in cerebral blood flow measured at rest using dynamic single photon emission computed tomography, which supports the hypothesis that, in man, the right hemisphere develops its functions earlier than the left.
Journal ArticleDOI
Late plasticity for language in a child's non-dominant hemisphere: a pre- and post-surgery fMRI study.
Lucie Hertz-Pannier,Catherine Chiron,Isabelle Jambaqué,Virginie Renaux-Kieffer,Pierre-Francois Van de Moortele,Olivier Delalande,Martine Fohlen,Francis Brunelle,Denis Le Bihan +8 more
TL;DR: This first serial fMRI study illustrates the great plasticity of the child's brain and the ability of the right hemisphere to take over some expressive language functions, even at a relatively late age and suggests a limit for removal of the dominant hemisphere beyond the age of 6 years, a classical limit for the critical period of language acquisition.
Journal ArticleDOI
Spectrum of SCN1A mutations in severe myoclonic epilepsy of infancy
Rima Nabbout,Elena Gennaro,B. Dalla Bernardina,Olivier Dulac,Francesca Madia,Enrico Bertini,Giuseppe Capovilla,Catherine Chiron,G. Cristofori,Maurizio Elia,Elena Fontana,R. Gaggero,Tiziana Granata,Renzo Guerrini,M. Loi,L. La Selva,Maria Luisa Lispi,A. Matricardi,Antonino Romeo,V. Tzolas,D. Valseriati,Pierangelo Veggiotti,Federico Vigevano,Louis Vallée,F. Dagna Bricarelli,Amedeo Bianchi,Federico Zara +26 more
TL;DR: A greater frequency of unilateral motor seizures was the only clinical difference between patients with SCN1A mutations and those without, suggesting that SMEI is genetically heterogeneous.