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Bart M. G. Smits
Researcher at Medical University of South Carolina
Publications - 29
Citations - 2139
Bart M. G. Smits is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Mutagenesis (molecular biology technique) & Gene. The author has an hindex of 18, co-authored 29 publications receiving 1842 citations. Previous affiliations of Bart M. G. Smits include Utrecht University & Morgridge Institute for Research.
Papers
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Journal ArticleDOI
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments.
Ning Leng,John A. Dawson,James A. Thomson,Victor Ruotti,Anna I. Rissman,Bart M. G. Smits,Jill D. Haag,Michael N. Gould,Ron Stewart,Christina Kendziorski +9 more
TL;DR: EBSeq is developed, using the merits of empirical Bayesian methods, for identifying DE isoforms in an RNA-seq experiment comparing two or more biological conditions and proves to be a robust approach for identifying De genes.
Journal ArticleDOI
Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system.
Judith R. Homberg,Jocelien D A Olivier,Bart M. G. Smits,Joram D. Mul,Josine Mudde,Mark Verheul,O.F.M. Nieuwenhuizen,Alexander R. Cools,Eric Ronken,Thomas I. F. H. Cremers,Anton N. M. Schoffelmeer,Bart A. Ellenbroek,Edwin Cuppen +12 more
TL;DR: In this paper, the authors describe the functional characterization of the serotonin transporter (SERT) knockout rat model, that is generated by N-ethyl-N-nitrosurea (ENU)-driven target-selected mutagenesis.
Journal ArticleDOI
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis.
Bart M. G. Smits,Josine Mudde,Jose van de Belt,Mark Verheul,Jocelien D A Olivier,Judith R. Homberg,Victor Guryev,Alexander R. Cools,Bart A. Ellenbroek,Ronald H.A. Plasterk,Edwin Cuppen +10 more
TL;DR: Robust, automated, and scaleable reverse genetic methodology based on ENU (N-ethyl-N-nitrosourea)-driven target-selected mutagenesis allows for the systematic generation of knockout and protein function altering alleles in the rat.
Journal ArticleDOI
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments
Ning Leng,John A. Dawson,James A. Thomson,Victor Ruotti,Anna I. Rissman,Bart M. G. Smits,Jill D. Haag,Michael N. Gould,Ron Stewart,Christina Kendziorski +9 more
TL;DR: Kendzior et al. as mentioned in this paper developed EBSeq for identifying differentially expressed (DE) genes and their corresponding isoforms on a genome-wide scale using RNA-seq experiments.
Journal ArticleDOI
Target-selected mutagenesis of the rat.
TL;DR: Proof of principle is reported for target-selected mutagenesis as a reverse genetic or knockout approach for the rat in order to manipulate gene function in vivo.