J
Jocelien D A Olivier
Researcher at University of Groningen
Publications - 83
Citations - 3337
Jocelien D A Olivier is an academic researcher from University of Groningen. The author has contributed to research in topics: Serotonin transporter & Serotonin. The author has an hindex of 26, co-authored 81 publications receiving 2949 citations. Previous affiliations of Jocelien D A Olivier include University of Texas Southwestern Medical Center & Uppsala University.
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Journal ArticleDOI
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
Michel Barrot,Jocelien D A Olivier,Linda I. Perrotti,Ralph J. DiLeone,Olivier Berton,Amelia J. Eisch,Soren Impey,Daniel R. Storm,Rachael L. Neve,Jerry C. P. Yin,Venetia Zachariou,Eric J. Nestler +11 more
TL;DR: It is shown that environmental stimuli regulate CRE-mediated transcription within the nucleus accumbens shell, and that changes in CREB activity within this brain area subsequently alter gating between emotional stimuli and their behavioral responses.
Journal ArticleDOI
Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system.
Judith R. Homberg,Jocelien D A Olivier,Bart M. G. Smits,Joram D. Mul,Josine Mudde,Mark Verheul,O.F.M. Nieuwenhuizen,Alexander R. Cools,Eric Ronken,Thomas I. F. H. Cremers,Anton N. M. Schoffelmeer,Bart A. Ellenbroek,Edwin Cuppen +12 more
TL;DR: In this paper, the authors describe the functional characterization of the serotonin transporter (SERT) knockout rat model, that is generated by N-ethyl-N-nitrosurea (ENU)-driven target-selected mutagenesis.
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A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders.
Jocelien D A Olivier,M G C Van Der Hart,R. P. L. van Swelm,Pieter J. Dederen,Judith R. Homberg,Thomas I. F. H. Cremers,Peter M.T. Deen,Edwin Cuppen,Alexander R. Cools,Bart A. Ellenbroek +9 more
TL;DR: It is demonstrated that SERT(-/-) rats show anxiety and depression-related behavior, independent of sex, as this knockout rat model may provide a valuable model to study anxiety- and Depression-related disorders in male and female rats.
Journal ArticleDOI
Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes
TL;DR: It is concluded that SERT function is conserved across mice and rats and that their behavioral profile arises from common neurodevelopmental alterations, which has heuristic value in understanding the mechanisms and behavioral outcome of SERT genetic variation in humans.
Journal ArticleDOI
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis.
Bart M. G. Smits,Josine Mudde,Jose van de Belt,Mark Verheul,Jocelien D A Olivier,Judith R. Homberg,Victor Guryev,Alexander R. Cools,Bart A. Ellenbroek,Ronald H.A. Plasterk,Edwin Cuppen +10 more
TL;DR: Robust, automated, and scaleable reverse genetic methodology based on ENU (N-ethyl-N-nitrosourea)-driven target-selected mutagenesis allows for the systematic generation of knockout and protein function altering alleles in the rat.