Ronald H.A. Plasterk

TL;DR: A high-quality sequence assembly of the zebrafish genome is generated, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map, providing a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebra fish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.

TL;DR: A role for Pasha is indicated in miRNA maturation and miRNA-mediated gene regulation in mature microRNAs and in the post-transcriptional level.

TL;DR: Current evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer, and the gain and loss of miRNA target sites appears to be causal to some genetic disorders.

TL;DR: A combination of phenotypic abnormalities and RNA analysis suggests a role for dcr-1 in a regulatory pathway comprised of small temporal RNA (let-7) and its target (e.g., lin-41).

TL;DR: Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.