Basak Eraslan

TL;DR: A quantitative proteome and transcriptome abundance atlas of 29 paired healthy human tissues from the Human Protein Atlas project revealed that hundreds of proteins, particularly in testis, could not be detected even for highly expressed mRNAs and that protein expression is often more stable across tissues than that of transcripts.

TL;DR: It is shown that a large fraction of PTR ratio variation in human tissues can be predicted from sequence, and it identifies many new candidate post‐transcriptional regulatory elements.

TL;DR: It is shown that a large fraction of PTR ratio variance across genes can be predicted from sequence and identified many new candidate post-transcriptional regulatory elements in the human genome.

TL;DR: A systematic, quantitative and deep proteome and transcriptome abundance atlas from 29 paired healthy human tissues from the Human Protein Atlas Project revealed that few proteins show truly tissue-specific expression, that vast differences between mRNA and protein quantities within and across tissues exist and that the expression levels of proteins are often more stable across tissues than those of transcripts.

TL;DR: In this article , the authors proposed compressed Perturb-seq, which measures multiple random perturbations per cell or multiple cells per droplet and computationally decompresses these measurements by leveraging the sparse structure of regulatory circuits.