L
Li-hua Li
Researcher at Technische Universität München
Publications - 4
Citations - 485
Li-hua Li is an academic researcher from Technische Universität München. The author has contributed to research in topics: Proteome & Proteogenomics. The author has an hindex of 3, co-authored 3 publications receiving 265 citations. Previous affiliations of Li-hua Li include Taipei Veterans General Hospital.
Papers
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Journal ArticleDOI
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Dongxue Wang,Basak Eraslan,Basak Eraslan,Thomas Wieland,Björn M. Hallström,Thomas A. Hopf,Daniel P Zolg,Jana Zecha,Anna Asplund,Li-hua Li,Chen Meng,Martin Frejno,Tobias Schmidt,Karsten Schnatbaum,Mathias Wilhelm,Fredrik Pontén,Mathias Uhlén,Julien Gagneur,Hannes Hahne,Bernhard Kuster,Bernhard Kuster +20 more
TL;DR: A quantitative proteome and transcriptome abundance atlas of 29 paired healthy human tissues from the Human Protein Atlas project revealed that hundreds of proteins, particularly in testis, could not be detected even for highly expressed mRNAs and that protein expression is often more stable across tissues than that of transcripts.
Book ChapterDOI
Hydrophilic Strong Anion Exchange (hSAX) Chromatography Enables Deep Fractionation of Tissue Proteomes
Benjamin Ruprecht,Benjamin Ruprecht,Dongxue Wang,Riccardo Zenezini Chiozzi,Li-hua Li,Hannes Hahne,Bernhard Kuster +6 more
TL;DR: The use of hSAX for the deep analysis of tissue proteomes is described and the identification of more than 100,000 unique peptide sequences representing over 10,195 proteins and 9,500 genes in 3 days of measurement time on a Q Exactive Plus mass spectrometer.
Posted ContentDOI
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Dongxue Wang,Basak Eraslan,Thomas Wieland,Björn M. Hallström,Thomas A. Hopf,Daniel P Zolg,Jana Zecha,Anna Asplund,Li-hua Li,Chen Meng,Martin Frejno,Tobias Schmidt,Karsten Schnatbaum,Mathias Wilhelm,Fredrik Pontén,Mathias Uhlén,Julien Gagneur,Hannes Hahne,Bernhard Kuster +18 more
TL;DR: A systematic, quantitative and deep proteome and transcriptome abundance atlas from 29 paired healthy human tissues from the Human Protein Atlas Project revealed that few proteins show truly tissue-specific expression, that vast differences between mRNA and protein quantities within and across tissues exist and that the expression levels of proteins are often more stable across tissues than those of transcripts.