B
Bastien Fricker
Researcher at French Institute of Health and Medical Research
Publications - 5
Citations - 391
Bastien Fricker is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Muscle atrophy. The author has an hindex of 4, co-authored 5 publications receiving 354 citations. Previous affiliations of Bastien Fricker include University of Strasbourg.
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Journal ArticleDOI
A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
Xiangjun Meng,Mili L. Leyva,Marjorie Jenny,Isabelle Gross,Samir Benosman,Bastien Fricker,Sébastien Harlepp,Pascal Hébraud,Anne Boos,Pauline Wlosik,Pierre Bischoff,Claude B. Sirlin,Michel Pfeffer,Jean-Philippe Loeffler,Christian Gaiddon +14 more
TL;DR: It is concluded that RDC11 acts by an atypical pathway involving CHOP and endoplasmic reticulum stress, and thus might provide an interesting alternative for anticancer therapy.
Journal ArticleDOI
Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis
Anissa Fergani,Hugues Oudart,Jose-Luis Gonzalez de Aguilar,Bastien Fricker,Frédérique René,Jean-François Hocquette,Vincent Meininger,Luc Dupuis,Jean-Philippe Loeffler +8 more
TL;DR: Findings show that energy metabolism in mSOD1 mice shifts toward an increase in the peripheral use of lipids, which probably accounts for the protective effect of dietary lipids in this model of ALS.
Journal ArticleDOI
Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis
Benoît Halter,Jose-Luis Gonzalez de Aguilar,Frédérique René,Susanne Petri,Bastien Fricker,Andoni Echaniz-Laguna,Luc Dupuis,Yves Larmet,Jean-Philippe Loeffler +8 more
TL;DR: This study provides strong evidence for the implication of oxidative stress in modulating Rad expression, in association with the initiation and progression of ALS muscle atrophy, and subjecting muscle to ischemia-reperfusion observed ROS accumulation and Rad overexpression.
Journal ArticleDOI
Evaluation tools and animal models of peripheral neuropathies.
TL;DR: This review presents the methods used to assess the peripheral neuropathies in the major available animal models and their main pathological characteristics, and discusses the emerging, recently developed tools that should allow to gain a better insight into the mechanisms underlying the peripheral Neuropathies.
Book ChapterDOI
Mouse Models with Motor Neuron Defects as a Tool for Deciphering Amyotrophic Lateral Sclerosis
TL;DR: The observation that point mutations in the copper/zinc superoxide dismutase gene causeAmyotrophic lateral sclerosis is a neurodegenerative disorder of unknown origin affecting primarily motor neurons.