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Luc Dupuis

Researcher at University of Strasbourg

Publications -  130
Citations -  11828

Luc Dupuis is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 43, co-authored 121 publications receiving 10420 citations. Previous affiliations of Luc Dupuis include French Institute of Health and Medical Research & University of Ulm.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model.

Luc Dupuis, +4 more
- 27 Jul 2004 - 
TL;DR: It is suggested that hypermetabolism, mainly of muscular origin, may represent by itself an additional driven force involved in increasing motor neuron vulnerability.
Journal ArticleDOI

Energy metabolism in amyotrophic lateral sclerosis.

Luc Dupuis, +5 more
- 01 Jan 2011 - 
TL;DR: In this paper, a negative contribution of defective energy metabolism to the overall pathogenic process was found in patients with amyotrophic lateral sclerosis (ALS), which is characterized by the progressive degeneration of upper and lower motor neurons.
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Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model

Caroline Rouaux, +8 more
- 23 May 2007 - 
TL;DR: Data show that neuroprotection can improve disease onset, but clearly provide evidence that one can uncouple MN survival from whole-animal survival and point to the neuromuscular junction perturbation as a primary event of ALS onset.
Journal ArticleDOI

Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

Luc Dupuis, +17 more
- 30 Apr 2009 - 
TL;DR: These findings provide the proof of principle that a muscle restricted mitochondrial defect is sufficient to generate motor neuron degeneration and suggest that therapeutic strategies targeted at muscle metabolism might prove useful for motor neuron diseases.