Batya Lerrer

TL;DR: Levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie‐restricted diet, implying that at least two sirtuins are involved in regulation of life‐span by nutrient availability.

TL;DR: Nicotinamide (NAM), a form of vitamin B-3, delayed differentiation and increased engraftment efficacy of cord blood-derived human CD34(+) cells cultured with cytokines, suggesting a critical function of SIRT1 in the regulation of hematopoietic stem cell activity and imply the clinical utility of NAM for ex vivo expansion of functional CD34 (+) cells.

TL;DR: The authors showed that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice, while maintaining hepatic glucose output and glucose homeostasis.

TL;DR: A dual role for Ku70 in apoptotic regulation is suggested; on one hand the association with Ku70 sequestered Bax away from the mitochondria and plays an antiapoptotic function and on the other hand this association mediates and promotes Bax deubiquitination which will block its labeling for proteasomal degradation and in this manner Ku70 will have a proAPoptotic role.

TL;DR: The authors demonstrate that SIRT6 acts as tumour suppressor by modulating the metabolism of cancer cells by inhibiting multiple glycolytic genes, including the glucose transporter Glut1 by promoter binding and -deacetylation.