J
John Kuriyan
Researcher at University of California, Berkeley
Publications - 282
Citations - 49707
John Kuriyan is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: DNA polymerase & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 103, co-authored 274 publications receiving 46431 citations. Previous affiliations of John Kuriyan include Memorial Sloan Kettering Cancer Center & California Institute for Quantitative Biosciences.
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Journal ArticleDOI
Crystallographic R Factor Refinement by Molecular Dynamics
TL;DR: Test cases showed that the need for manual corrections during refinement of macromolecular crystal structures is reduced and the dynamics calculation moved residues that were misplaced by more than 3 angstroms into the correct positions without human intervention.
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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
Thomas Schindler,William Bornmann,Patricia Pellicena,W. Todd Miller,Bayard D. Clarkson,John Kuriyan +5 more
TL;DR: The results suggest that compounds that exploit the distinctive inactivation mechanisms of individual protein kinases can achieve both high affinity and high specificity.
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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
Neil P. Shah,John Nicoll,Bhushan Nagar,Mercedes E. Gorre,Ronald Paquette,John Kuriyan,John Kuriyan,Charles L. Sawyers +7 more
TL;DR: Through sequencing analysis of blood or bone marrow samples from patients with chronic myeloid leukemia, BCR-ABL kinase domain mutations in 29 of 32 patients whose disease relapsed after an initial response to the tyrosine kinase inhibitor imatinib are identified.
Journal ArticleDOI
The Conformational Plasticity of Protein Kinases
TL;DR: Crystal structures of inactive kinases have revealed a remarkable plasticity in the kinase domain that allows the adoption of distinct conformations in response to interactions with specific regulatory domains or proteins.
Structural Mechanism for STI-571 Inhibition of Abelson
Thomas Schindler,William G. Bornmann,Patricia Pellicena,W. Todd Miller,Bayard D. Clarkson,John Kuriyan +5 more
TL;DR: The crystal structure of the catalytic domain of the Abelson tyrosine kinase (Abl) complexed to a variant of STI-571 is reported in this paper.