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Beat A. Imhof
Researcher at University of Geneva
Publications - 84
Citations - 8081
Beat A. Imhof is an academic researcher from University of Geneva. The author has contributed to research in topics: Cell adhesion molecule & Integrin. The author has an hindex of 47, co-authored 83 publications receiving 7762 citations. Previous affiliations of Beat A. Imhof include Basel Institute for Immunology & Geneva College.
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Adhesion mechanisms regulating the migration of monocytes
TL;DR: The signals by which chemokines regulate the leukocyte-adhesion molecules that are essential for transendothelial migration are discussed, and the routes taken by monocytes and myeloid dendritic cells to reach their final destination are described.
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Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion
Dirk Lehnert,Bernhard Wehrle-Haller,Christian David,Ulrich Weiland,Christoph Ballestrem,Beat A. Imhof,Martin Bastmeyer +6 more
TL;DR: Knowing the geometrical limits of ECM binding sites required for cell attachment and spreading is essential for an understanding of cell adhesion and migration, and for the design of artificial surfaces that optimally interact with cells in a living tissue.
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CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.
TL;DR: Identification of a further versatile adhesion pair broadens the current understanding of leukocyte-endothelial interactions and may provide the basis for the treatment of inflammatory disorders and metastasis formation.
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Dual role of macrophages in tumor growth and angiogenesis
TL;DR: It is notable that tumor‐associated macrophages promote the proliferation of tumor cells directly by secreting growth factors and participate in tumor progression by acting on endothelial cells and thus promoting the neovascularization of the tumor.