Beate Henrichfreise

TL;DR: Eleven out of 12 strains and 3 out of 10 strains from CF patients and non-CF patients, respectively, were hypermutable, which should be taken into consideration for the treatment of multiresistant P. aeruginosa.

TL;DR: The hypothesis that the necessity for maintaining lipid II biosynthesis in cell wall‐lacking bacteria reflects an essential role of the precursor in prokaryotic cell division is discussed and the lipid II pathway may be exploited as an antibacterial target for chlamydial and filarial infections.

TL;DR: The efficient production of MraY homologues from various human pathogens by synthetic cell-free expression approaches and their subsequent characterization are reported and the inhibition of the in vitro lipid II biosynthesis with the specific inhibitors fosfomycin, feglymycin, and tunicamycin is demonstrated.

TL;DR: The findings suggest that MreB is involved in tethering biosynthesis of lipid II and as such may be necessary for maintaining a functional divisome machinery in Chlamydiaceae.

TL;DR: The emergence of metallo-β-lactamase (MBL)-producing pathogens is an increasing therapeutic problem; there is no clinically useful inhibitor available.