Kelly L. Johnston

TL;DR: Diacyl WoLP induced systemic tumor necrosis factor-α and neutrophil-mediated keratitis in mice and drove interferon-γ-dependent CD4+ T cell polarization and antibody switching.

TL;DR: Doxycycline is well tolerated in patients co-infected with moderate intensities of L. loa parasitaemias and the viability of female adult worms was significantly reduced in doxycycline treated groups and the macrofilaricidal and sterilising activity was unaffected by the addition of ivermectin.

TL;DR: A high-throughput screen of AstraZeneca’s 1.3 million in-house compound library is performed and 5 novel chemotypes with faster in vitro kill rates than existing anti-Wolbachia drugs are identified that cure onchocerciasis and lymphatic filariasis.

TL;DR: The cellular and molecular basis of Wolbachia filarial interactions are reviewed and the key processes provided by the endosymbiont upon which the nematodes have become entirely dependent are highlighted.

TL;DR: A role for Wolbachia is promoted in contributing toward the dysregulated and tolerized immunological phenotype that accompanies the majority of human filarial infections.