Tanja Schneider

TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.

TL;DR: Plectasin, a fungal defensin, acts by directly binding the bacterial cell-wall precursor Lipid II, and a wide range of genetic and biochemical approaches identify cell- wall biosynthesis as the pathway targeted by plectasin.

TL;DR: It is reported that daptomycin perturbs fluid microdomains in bacterial cell membranes, thereby interfering with membrane-bound cell wall and lipid synthesis processes, and adding a different perspective as to how membrane-active antibiotics can kill bacteria.

TL;DR: Modifications of the cell wall appear to also contribute to DAP‐R, including enhanced expression of the dlt operon (involved in d‐alanylation of CW teichoic acids) and progressive CW thickening.

TL;DR: With in-depth analysis of the activity of more recently identified inhibitors and with the availability of novel techniques for studying prokaryotic cell biology, new insights were obtained into the molecular organisation of the cell wall biosynthesis machinery and its interconnections with other vital cellular processes such as cell division.