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Béatrice Pérarnau
Researcher at Pasteur Institute
Publications - 11
Citations - 2030
Béatrice Pérarnau is an academic researcher from Pasteur Institute. The author has contributed to research in topics: CD8 & MHC class I. The author has an hindex of 10, co-authored 11 publications receiving 1992 citations. Previous affiliations of Béatrice Pérarnau include French Institute of Health and Medical Research.
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Journal ArticleDOI
Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells
Corinne Tanchot,François A. Lemonnier,François A. Lemonnier,Béatrice Pérarnau,Béatrice Pérarnau,Antonio A. Freitas,Antonio A. Freitas,Benedita Rocha,Benedita Rocha +8 more
TL;DR: Maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.
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HLA-A2.1–restricted Education and Cytolytic Activity of CD8+ T Lymphocytes from β2 Microglobulin (β2m) HLA-A2.1 Monochain Transgenic H-2Db β2m Double Knockout Mice
TL;DR: Three different HLA-A2.1 monochains were engineered in which either the human or mouse β2-microglobulin (β2m) is covalently linked to the NH2 terminus of the heavy chain by a 15– amino acid long peptide, and the selected HHD construct was introduced by transgenesis in H-2Db/− β2m−/− double knockout mice.
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Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses.
Béatrice Pérarnau,Marie Françoise Saron,Bernardo Reina San Martin,Nathalie Bervas,Helena Ong,Mark J. Soloski,Austin Smith,Jan Ure,Jean Edouard Gairin,François A. Lemonnier +9 more
TL;DR: Choriomeningitis of H2Db KO mice was linked to the development of a subdominant H2Kb‐restricted cytotoxic T lymphocyte response and should represent useful tools to evaluate the immunological potentials of individual MHC class I molecules.
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Major histocompatibility complex (MHC) class I KbDb −/− deficient mice possess functional CD8+ T cells and natural killer cells
Yulia Vugmeyster,Rickard Glas,Béatrice Pérarnau,François Lemonnier,Herman N. Eisen,Hidde L. Ploegh +5 more
TL;DR: A minor population of functionally competent peripheral CD8+ T cells capable of strong cytotoxic activity arises in the complete absence of classical MHC class Ia molecules.
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MHC class Ia-restricted T cells partially account for beta 2- microglobulin-dependent resistance to Mycobacterium tuberculosis
Michael S. Rolph,Bärbel Raupach,Heidrun H. C. Köbernick,Helen L. Collins,Béatrice Pérarnau,François A. Lemonnier,Stefan H. E. Kaufmann +6 more
TL;DR: In this paper, the role of MHC class Ia in resistance to M. tuberculosis infection in mice has been defined, and the authors found that mice deficient in a single MHC-class Ia molecule, either H2-K(b) or H2D(b), were essentially identical to that observed in wild-type mice.