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Beatrice Rondinelli
Researcher at Harvard University
Publications - 6
Citations - 1556
Beatrice Rondinelli is an academic researcher from Harvard University. The author has contributed to research in topics: Genome instability & DNA repair. The author has an hindex of 5, co-authored 5 publications receiving 1188 citations. Previous affiliations of Beatrice Rondinelli include Vita-Salute San Raffaele University.
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Journal ArticleDOI
Repair Pathway Choices and Consequences at the Double-Strand Break
TL;DR: Alternative error-prone DSB repair pathways, namely alternative end joining (alt-EJ) and single-strand annealing (SSA) have been recently shown to operate in many different conditions and to contribute to genome rearrangements and oncogenic transformation.
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EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Beatrice Rondinelli,Ewa Gogola,Hatice Yücel,Alexandra A. Duarte,Marieke van de Ven,Roxanne van der Sluijs,Roxanne van der Sluijs,Panagiotis A. Konstantinopoulos,Jos Jonkers,Raphael Ceccaldi,Sven Rottenberg,Sven Rottenberg,Alan D. D'Andrea +12 more
TL;DR: It is shown that EZH2 localizes at stalled forks where it methylates Lys27 on histone 3 (H3K27me3), mediating recruitment of the MUS81 nuclease, which promotes PARPi resistance in BRCA2-deficient cells.
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FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair
Zeina Kais,Beatrice Rondinelli,Amie Holmes,Colin O’Leary,David Kozono,Alan D. D'Andrea,Raphael Ceccaldi +6 more
TL;DR: The results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2, and they identify FAN CD2 as a central player orchestrating DNA repair pathway choice at the replication fork.
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Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer
Beatrice Rondinelli,Beatrice Rondinelli,Dalia Rosano,Elena Antonini,Michela Frenquelli,Laura Montanini,Dachuan Huang,Simona Segalla,Kosuke Yoshihara,Samir B. Amin,Dejan Lazarevic,Roel G.W. Verhaak,P. Andrew Futreal,Luciano Di Croce,Lynda Chin,Davide Cittaro,Giovanni Tonon +16 more
TL;DR: The results shed light on a mechanism that underlies genomic instability in sporadic cancers and suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.
Journal ArticleDOI
H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing.
Beatrice Rondinelli,Hélène Schwerer,Elena Antonini,Marco Gaviraghi,Alessio Lupi,Michela Frenquelli,Davide Cittaro,Simona Segalla,Jean-Marc Lemaitre,Giovanni Tonon +9 more
TL;DR: It is shown that the histone demethylase KDM5C/JARID1C is required for proper DNA replication at early origins, and a prominent role for JARIDs1C in a specific phase of DNA replication in mammalian cells is pointed to through its dem methylase activity on H3K4me3.