Smina Ait-Yahia

TL;DR: Observations suggest that hIL-17 may constitute an early initiator of the T cell-dependent inflammmatory reaction; and an element of the cytokine network that bridges the immune system to hematopoiesis.

TL;DR: The observation that CCR6 mRNA expression decreases progressively as DCs mature, whereas CCR7 mRNA expression is sharply upregulated, provides a likely explanation for the changes in chemokine responsiveness, and suggests a role for MIP-3α/CCR6 in recruitment of immature DCs at site of injury and for Mip-3β/CCr7 in accumulation of antigen-loaded mature DCs in T cell–rich areas.

TL;DR: The pattern of cytokines expressed by two independent dendritic cell (DC) subpopulations generated in vitro from human cord blood CD34+ progenitors cultured with granulocyte-macrophage CSF and TNF-alpha seemed more closely related to germinal center d endritic cellsGCDC than to Langerhans cells.

TL;DR: A novel lysosome-associated membrane glycoprotein localized on chromosome 3q26.3-q27, DC-LAMP, which is homologous to CD68, was identified and found in the MHC class II compartment immediately before the translocation of MHCclass II molecules to the cell surface, after which it concentrates into perinuclear l Lysosomes.

TL;DR: It is shown that myeloid DCs rapidly recruited by adjuvants into the buccal mucosa or skin are essential for CD8+ T cell crosspriming.