Bedrick B. Gadea

TL;DR: It is demonstrated that high levels of cathepsin protease activity are induced in the majority of macrophages in the microenvironment of pancreatic islet cancers, mammary tumors, and lung metastases during malignant progression and that interleukin-4 (IL-4) is responsible for inducing cat hepsin activity in macrophage in vitro and in vivo.

TL;DR: The mode of action presented here demonstrates that processing and activation of proheparanase can be brought about solely by cathepsin L, and offers new strategies for inhibiting the prometastatic, proangiogenic, and proinflammatory activities of heparanases.

TL;DR: The results show that macrophages are important for promoting PNET development and suggest that additional factors contribute to the recruitment and survival of myeloid cells in RT2 tumors in the absence of CSF-1.

TL;DR: A recurring theme throughout this review will be that of balance: maintaining the normal functions of these co-opted cells, yet selectively inhibiting their pro-tumourigenic functions.

TL;DR: It is shown that high levels of cathepsin protease activity are induced in the majority of macrophages in the microenvironment of pancreatic islet cancers, mammary tumors and lung metastases during malignant progression, and it is demonstrated that interleukin (IL)-4 is responsible for inducing cat hepsin activity in macrophage in vitro and in vivo.