Tanaya Shree

TL;DR: It is demonstrated that high levels of cathepsin protease activity are induced in the majority of macrophages in the microenvironment of pancreatic islet cancers, mammary tumors, and lung metastases during malignant progression and that interleukin-4 (IL-4) is responsible for inducing cat hepsin activity in macrophage in vitro and in vivo.

TL;DR: Increased macrophage infiltration and cathepsin protease levels in mammary tumors following paclitaxel (Taxol) chemotherapy are found and this study highlights the importance of integrated targeting of the tumor and its microenvironment and implicates macrophages andCathepsins in blunting chemotherapeutic response.

TL;DR: Although critical for degeneration of the soma, Fas deficiency did not significantly prevent the reduction of dopaminergic terminal fibers within the striatum or normalize the activation of striatal microglia and elevation of the postsynaptic activity marker ΔFosB induced by denervation.

TL;DR: The identification of VBY-825 as a new and effective anti-tumor drug encourages the therapeutic application of cathepsin inhibitors in cancer.

TL;DR: C-Jun/JNK is activated following DNA damage and it is proposed that c-Jun is regulated by the JNK and CDK pathways and that both must be activated for efficient c- Jun activation to occur.