B
Benbo Song
Researcher at University of Michigan
Publications - 17
Citations - 4736
Benbo Song is an academic researcher from University of Michigan. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 14, co-authored 16 publications receiving 4346 citations. Previous affiliations of Benbo Song include Howard Hughes Medical Institute.
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Journal ArticleDOI
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Donalyn Scheuner,Benbo Song,Edward L. McEwen,Chuan Liu,Ross Laybutt,Patrick J. Gillespie,Thom Saunders,Susan Bonner-Weir,Randal J. Kaufman +8 more
TL;DR: It is demonstrated that regulation of translation through eIF2alpha phosphorylation is essential for the ER stress response and in vivo glucose homeostasis.
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Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
TL;DR: In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved beta cell ultrastructure and promoted cell survival and increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage.
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ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress
Jun Wu,D. Thomas Rutkowski,Meghan Dubois,Jayanth Swathirajan,Thomas L. Saunders,Junying Wang,Benbo Song,Grace D.-Y. Yau,Randal J. Kaufman +8 more
TL;DR: The results suggest that the vertebrate ATF6alpha pathway evolved to maintain ER function when cells are challenged with chronic stress and provide a rationale for the overlap among the three UPR pathways.
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UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
D. Thomas Rutkowski,Jun Wu,Sung Hoon Back,Michael U. Callaghan,Michael U. Callaghan,Sean P. Ferris,Jahangir Iqbal,Robert Clark,Hongzhi Miao,Justin R. Hassler,Jamie L. Fornek,Michael G. Katze,M. Mahmood Hussain,Benbo Song,Jayanth Swathirajan,Junying Wang,Grace D.-Y. Yau,Randal J. Kaufman +17 more
TL;DR: An unanticipated direct link between ER homeostasis and the transcriptional regulation of metabolism is revealed, and mechanisms by which ER stress might underlie fatty liver disease are suggested.
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Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure
Edward McEwen,Nancy Kedersha,Benbo Song,Donalyn L Scheuner,Natalie Gilks,Anping Han,J J Chen,Paul A. Anderson,Randal J. Kaufman,Randal J. Kaufman +9 more
TL;DR: An essential role for HRI is demonstrated in mediating arsenite stress-induced phosphorylation of eukaryotic translation initiation factor 2α, inhibition of protein synthesis, stress granule formation, and survival.