Benito Ordaz

TL;DR: It is demonstrated that intracellular Ca2+ has dual and opposite effects on the activation of TRPC5, whereas the CIRB domain is critical for the overall response of receptor-inducedTRPC5 channel activation.

TL;DR: Water gain in the brain consequent to hyponatremia is counteracted by mechanisms that initially include a compensatory displacement of liquid from the interstitial space to cerebrospinal fluid and systemic circulation and subsequently an active reduction in cell water accomplished by extrusion of intracellular osmolytes to reach osmotic equilibrium.

TL;DR: The data suggest that βAP acutely affects proper hippocampal function through a Fyn‐dependent mechanism, and proposes that such alteration might be related to the cognitive impairment observed, at least, during the early phases of Alzheimer's disease.

TL;DR: Mechanistically, it is shown that pyramidal neurons and some parvalbumin-positive interneurons in 1-month-old triple-transgenic AD mice accumulate hyperphosphorylated Tau protein and that this accumulation correlates with changes in theta oscillations in hippocampal neurons, suggesting neuronal responses that compensate for brain circuit overexcitation.

TL;DR: Results present evidence of substantial differences between the efflux of taurine and that of GABA and glutamate, which besides a possible role as osmolytes, have a main function as synaptic transmitters.