H
Hugo Balleza-Tapia
Researcher at Karolinska Institutet
Publications - 13
Citations - 290
Hugo Balleza-Tapia is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Hippocampal formation & Amyloid beta. The author has an hindex of 7, co-authored 12 publications receiving 211 citations. Previous affiliations of Hugo Balleza-Tapia include CINVESTAV.
Papers
More filters
Journal ArticleDOI
Beta-amyloid protein (25-35) disrupts hippocampal network activity: role of Fyn-kinase.
Fernando Peña,Benito Ordaz,Hugo Balleza-Tapia,Ramón Bernal-Pedraza,Abraham Márquez-Ramos,Liliana Carmona-Aparicio,Magda Giordano +6 more
TL;DR: The data suggest that βAP acutely affects proper hippocampal function through a Fyn‐dependent mechanism, and proposes that such alteration might be related to the cognitive impairment observed, at least, during the early phases of Alzheimer's disease.
Journal ArticleDOI
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.
Hugo Balleza-Tapia,Sophie Crux,Sophie Crux,Yuniesky Andrade-Talavera,Pablo Dolz-Gaitón,Daniela Papadia,Gefei Chen,Jan Johansson,André Fisahn +8 more
TL;DR: It is found that the TrpV1-receptor agonist capsaicin rescues Aβ-induced degradation of hippocampal gamma oscillations by reversing both the desynchronization of AP firing in CA3 pyramidal cells and the shift in excitatory/inhibitory current balance.
Journal ArticleDOI
Beta-like hippocampal network activity is differentially affected by amyloid beta peptides.
Alvaro Adaya-Villanueva,Benito Ordaz,Hugo Balleza-Tapia,Abraham Márquez-Ramos,Fernando Peña-Ortega +4 more
TL;DR: The results support the idea that different amyloid peptides might alter specific cellular mechanisms related to the generation of specific neuronal network activities, instead of a generalized inhibitory effect of Abeta peptides on neuronal network function.
Journal ArticleDOI
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.
Luis Enrique Arroyo-García,Arturo G. Isla,Yuniesky Andrade-Talavera,Hugo Balleza-Tapia,Raúl Loera-Valencia,Laura Alvarez-Jimenez,Giusy Pizzirusso,Simone Tambaro,Per Nilsson,André Fisahn +9 more
TL;DR: In Alzheimer's disease, the accumulation of amyloid-β (Aβ) correlates with degradation of cognition-relevant gamma oscillations as discussed by the authors, and the degradation correlates with increased Aβ1-42 concentration in the brain.
Journal ArticleDOI
Amyloid beta 1-42 inhibits entorhinal cortex activity in the beta-gamma range: role of GSK-3.
Fernando Peña-Ortega,Angeles Solis-Cisneros,Benito Ordaz,Hugo Balleza-Tapia,Juan Javier López-Guerrero +4 more
TL;DR: The results suggest that amyloid beta-induced inhibition of entorhinal cortex beta-gamma activity involves GSK-3 activation, which may provide a molecular mechanism for amyloidsbeta-induced neural network disruption and support the use of GSK3 inhibitors to treat Alzheimer Disease.