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Benjamin D. Matthews
Researcher at Boston Children's Hospital
Publications - 34
Citations - 6531
Benjamin D. Matthews is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Integrin & Mechanotransduction. The author has an hindex of 19, co-authored 31 publications receiving 5461 citations. Previous affiliations of Benjamin D. Matthews include Boston University & Indiana University.
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Journal ArticleDOI
Reconstituting Organ-Level Lung Functions on a Chip
Dongeun Huh,Benjamin D. Matthews,Akiko Mammoto,Martin Montoya-Zavala,Martin Montoya-Zavala,Hong Yuan Hsin,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +8 more
TL;DR: Mechanically active “organ-on-a-chip” microdevices that reconstitute tissue-tissue interfaces critical to organ function may expand the capabilities of cell culture models and provide low-cost alternatives to animal and clinical studies for drug screening and toxicology applications.
Journal ArticleDOI
A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
Dongeun Huh,Daniel C. Leslie,Daniel C. Leslie,Benjamin D. Matthews,Jacob P. Fraser,Samuel Jurek,Geraldine A. Hamilton,Kevin S. Thorneloe,Michael Allen McAlexander,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +11 more
TL;DR: The human lung on a microfluidic chip is recreated and shown that it not only mimics lung function in response to IL-2 and mechanical strain but also successfully predicts the activity of a new drug for pulmonary edema.
Journal ArticleDOI
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels
TL;DR: Cell use multiple mechanisms to sense and respond to static and dynamic changes in the level of mechanical stress applied to integrins, and these responses differed biochemically.
Journal ArticleDOI
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Netanel Korin,Mathumai Kanapathipillai,Benjamin D. Matthews,Marilena Crescente,Marilena Crescente,Alexander Brill,Alexander Brill,Tadanori Mammoto,Kaustabh Ghosh,Samuel Jurek,Sidi A. Bencherif,Sidi A. Bencherif,Deen Bhatta,Ahmet U. Coskun,Charles L. Feldman,Denisa D. Wagner,Denisa D. Wagner,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +19 more
TL;DR: A biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism—in the same way platelets do—to deliver drugs to obstructed blood vessels offers a potential new approach for treatment of life-threatening diseases that result from acute vascular occlusion.
Journal ArticleDOI
TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling
Charles K. Thodeti,Benjamin D. Matthews,Arvind Ravi,Akiko Mammoto,Kaustabh Ghosh,Abigail L. Bracha,Donald E. Ingber +6 more
TL;DR: It is shown that cyclically stretching capillary endothelial cells adherent to flexible extracellular matrix substrates activates mechanosensitive TRPV4 (transient receptor potential vanilloid 4) ion channels that stimulate phosphatidylinositol 3-kinase–dependent activation and binding of additional β1 integrin receptors, which promotes cytoskeletal remodeling and cell reorientation.