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Benjamin J. Blaise
Researcher at Imperial College London
Publications - 33
Citations - 981
Benjamin J. Blaise is an academic researcher from Imperial College London. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 15, co-authored 28 publications receiving 831 citations. Previous affiliations of Benjamin J. Blaise include University of Coimbra & Centre national de la recherche scientifique.
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Journal ArticleDOI
A serum nuclear magnetic resonance-based metabolomic signature of advanced metastatic human breast cancer
Elodie Jobard,Clément Pontoizeau,Benjamin J. Blaise,Thomas Bachelot,Bénédicte Elena-Herrmann,Olivier Tredan +5 more
TL;DR: A NMR-based metabolic phenotyping study aiming at identifying coordinated metabolic serum changes associated with advanced metastatic breast cancer (MBC) in comparison to the localized early disease (EBC).
Journal ArticleDOI
Metabotyping of Caenorhabditis elegans reveals latent phenotypes.
Benjamin J. Blaise,Jean Giacomotto,Bénédicte Elena,Marc-Emmanuel Dumas,Pierre Toulhoat,Laurent Ségalat,Lyndon Emsley +6 more
TL;DR: 1H high-resolution magic angle spinning NMR spectroscopy (1H HRMAS-NMR) is used to reveal the latent phenotype associated to superoxide dismutase and catalase C. elegans mutations, both involved in the elimination of radical oxidative species.
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Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.
Laetitia Shintu,Régis Baudoin,Vincent Navratil,Jean-Matthieu Prot,Clément Pontoizeau,Marianne Defernez,Benjamin J. Blaise,Céline Domange,Alexandre R.R. Pery,Pierre Toulhoat,Cécile Legallais,Céline Brochot,Eric Leclerc,Marc-Emmanuel Dumas,Marc-Emmanuel Dumas +14 more
TL;DR: The integration of microtechnology, cell culture in microfluidic biochips, and metabolic profiling opens the development of so-called "metabolomics-on-a-chip" assays in pharmaceutical and environmental toxicology.
Journal ArticleDOI
Statistical recoupling prior to significance testing in nuclear magnetic resonance based metabonomics.
Benjamin J. Blaise,Laetitia Shintu,Bénédicte Elena,Lyndon Emsley,Marc-Emmanuel Dumas,Pierre Toulhoat +5 more
TL;DR: An algorithm based on the landscape of the covariance/correlation ratio of consecutive variables along the chemical shift axis to restore, prior to significance testing, the spectral dependency and recouple variables in clusters which correspond to physical, chemical, and biological entities: statistical recoupling of variables (SRV).
Journal ArticleDOI
Power Analysis and Sample Size Determination in Metabolic Phenotyping.
Benjamin J. Blaise,Gonçalo D S Correia,Adrienne Tin,J. Hunter Young,Anne-Claire Vergnaud,Matthew R. Lewis,Jake T M Pearce,Paul Elliott,Jeremy K. Nicholson,Elaine Holmes,Timothy M. D. Ebbels +10 more
TL;DR: This work introduces a new approach, based on multivariate simulation, which deals effectively with the highly correlated structure and high-dimensionality of metabolic phenotyping data, and investigates the complex relationship between sample size, power, and effect size for real multivariate data sets.