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Benjamin L. Larson
Researcher at Massachusetts Institute of Technology
Publications - 21
Citations - 5839
Benjamin L. Larson is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Mesenchymal stem cell & Stromal cell. The author has an hindex of 18, co-authored 21 publications receiving 5453 citations. Previous affiliations of Benjamin L. Larson include Texas A&M Health Science Center College of Medicine & Tulane University.
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Journal ArticleDOI
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6
Ryang Hwa Lee,Andrey A. Pulin,Min Jeong Seo,Daniel J. Kota,Daniel J. Kota,Joni Ylostalo,Joni Ylostalo,Benjamin L. Larson,Benjamin L. Larson,Laura Semprun-Prieto,Patrice Delafontaine,Darwin J. Prockop,Darwin J. Prockop +12 more
TL;DR: Quantitative assays for human DNA and mRNA were used to examine the paradox that intravenously infused human multipotent stromal cells (hMSCs) can enhance tissue repair without significant engraftment and suggest that improvements in animal models and patients after i.v. infusions of MSCs are at least in part explained by activation of M SCs to secrete TSG-6.
Journal ArticleDOI
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential
Alexandra Peister,Jason A. Mellad,Jason A. Mellad,Benjamin L. Larson,Benjamin L. Larson,Brett Hall,Brett Hall,Laura F. Gibson,Laura F. Gibson,Darwin J. Prockop,Darwin J. Prockop +10 more
TL;DR: A protocol that provides rapidly expanding MSCs from 5 strains of inbred mice with differences in their media requirements for optimal growth, rates of propagation, and presence of the surface epitopes CD34, stem cell antigen-1 (Sca-1), and vascular cell adhesion molecule 1 (VCAM-1).
Journal ArticleDOI
Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
Ichiro Sekiya,Benjamin L. Larson,Jason Smith,Radhika Pochampally,Jian-Guo Cui,Darwin J. Prockop +5 more
TL;DR: Assays for adipogenesis demonstrated that the adipogenic potential of cultures was directly related to their ability to generate single‐cell‐derived colonies and their enrichment for RS‐1A cells, and cultures enriched for RS-1B cells showed the greatest potential to differentiate into cartilage in a serum‐free system.
Journal ArticleDOI
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis
TL;DR: The results indicate that the simplicity of the system makes it possible to define in detail the cellular and molecular events during chondrogenesis.
Journal ArticleDOI
Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs).
TL;DR: Microarray assays demonstrated time‐dependent increases in expression of 67 genes, including 2 genes for transcription factors that were not previously shown to be expressed during adipogenesis of human MSCs.