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Benjamin P. Lewis
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 19687
Benjamin P. Lewis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 7, co-authored 8 publications receiving 18727 citations. Previous affiliations of Benjamin P. Lewis include University of California & Harvard University.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
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The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Kyle Kai-How Farh,Andrew Grimson,Calvin H. Jan,Benjamin P. Lewis,Wendy K. Johnston,Lee P. Lim,Christopher B. Burge,David P. Bartel +7 more
TL;DR: It is found that these conserved targets are often highly expressed at developmental stages before miRNA expression and that their levels tend to fall as the miRNA that targets them begins to accumulate.
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Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans
TL;DR: It is proposed that regulated unproductive splice and translation (RUST), through the coupling of alternative splicing and NMD, may be a pervasive, underappreciated means of regulating protein expression.
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Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes.
Richard E. Green,Benjamin P. Lewis,Benjamin P. Lewis,R. Tyler Hillman,Marco Blanchette,Liana F. Lareau,Aaron T. Garnett,Donald C. Rio,Steven E. Brenner,Steven E. Brenner +9 more
TL;DR: The initial experimental studies are consistent with predictions and suggest an unappreciated role for NMD in several human diseases.