Benjamin Weide

TL;DR: Patients with cutaneous metastasis without lymph node involvement in stage III and with soft-tissue metastasis in stage IV showed unexpected favorable survival rates after intratumoral treatment with IL-2, associated with increased complete and partial responses in subsequent chemotherapies.

TL;DR: The tumor microenvironment-associated protein S100A8/A9 serves as a novel prognostic marker for metastasis and survival of metastatic melanoma patients and predicts response to immunotherapy with pembrolizumab, underscoring the significance of tumor micro environment-derived factors as suitable biomarkers for melanoma.

TL;DR: In this article, the authors explored the impact of selective BRAF inhibitors on the hosts' immune system using flow cytometry and multiplex assays, and found that vemurafenib but not dabrafenib decreases patients peripheral lymphocyte counts and alters CD4 + T cell phenotype and function.

TL;DR: It is feasible to generate CAR-NKT cells by using mRNA electroporation, and their CAR-mediated cytotoxicity is at least equal to that of conventional CAR-T cells, while their intrinsic cytotoxic activity is maintained.

TL;DR: It is demonstrated that the widely available 18F-FDG-PET modality is an applicable translational tool that has high potential to stratify patients at an early time point and is capable of detecting immunotherapy-associated metabolic changes in the primary and secondary lymphoid organs induced by the systemic immune response after CIT.