J
Jürgen Bauer
Researcher at University of Tübingen
Publications - 147
Citations - 12048
Jürgen Bauer is an academic researcher from University of Tübingen. The author has contributed to research in topics: Melanoma & Epilepsy. The author has an hindex of 38, co-authored 145 publications receiving 11074 citations. Previous affiliations of Jürgen Bauer include University of California, San Francisco & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
Journal ArticleDOI
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Catherine D. Van Raamsdonk,Vladimir Bezrookove,Gary G. R. Green,Jürgen Bauer,Lona Gaugler,Joan M. O'Brien,Elizabeth M. Simpson,Gregory S. Barsh,Boris C. Bastian +8 more
TL;DR: In this paper, the authors reported frequent mutations in the heterotrimeric G protein alpha-subunit, GNAQ, in blue naevi (83%), and ocular melanoma of the uvea (46%).
Journal ArticleDOI
Dermcidin: a novel human antibiotic peptide secreted by sweat glands.
Birgit Schittek,Rainer Hipfel,Birgit Sauer,Jürgen Bauer,Hubert Kalbacher,Stefan Stevanovic,Markus Schirle,Kristina Schroeder,Nikolaus Blin,Friedegund Meier,Gernot Rassner,Claus Garbe +11 more
TL;DR: In sweat, a proteolytically processed 47–amino acid peptide was generated that showed antimicrobial activity in response to a variety of pathogenic microorganisms, indicating that sweat plays a role in the regulation of human skin flora through the presence of an antimicrobial peptide.
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T-helper-1-cell cytokines drive cancer into senescence
Heidi Braumüller,Thomas Wieder,Ellen Brenner,Sonja Aßmann,Matthias Hahn,Mohammed Alkhaled,Karin Schilbach,Frank Essmann,Manfred Kneilling,Christoph M. Griessinger,Felicia Ranta,Susanne Ullrich,Ralph Mocikat,Kilian Braungart,Tarun Mehra,Birgit Fehrenbacher,Julia Berdel,Heike Niessner,Friedegund Meier,Maries van den Broek,Hans-Ulrich Häring,Rupert Handgretinger,Leticia Quintanilla-Martinez,Falko Fend,Marina Pesic,Jürgen Bauer,Lars Zender,Martin Schaller,Klaus Schulze-Osthoff,Martin Röcken +29 more
TL;DR: The combined action of the T-helper-1-cell cytokines IFN-γ and tumour necrosis factor (TNF) directly induces permanent growth arrest in cancers, a general mechanism for arresting cancer progression.
Journal ArticleDOI
MC1R germline variants confer risk for BRAF-mutant melanoma
Maria Teresa Landi,Jürgen Bauer,Jürgen Bauer,Ruth M. Pfeiffer,David E. Elder,Benjamin J. Hulley,Paola Minghetti,Donato Calista,Peter A. Kanetsky,Daniel Pinkel,Boris C. Bastian +10 more
TL;DR: In two independent Caucasian populations, it is shown that MC1R variants are strongly associated with BRAF mutations in non-CSD melanomas and in this tumor subtype, the risk for melanoma associated withMC1R is due to an increase in risk of developing melanomas with BRAFs.