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Benoit Chabot
Researcher at Université de Sherbrooke
Publications - 135
Citations - 11404
Benoit Chabot is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 55, co-authored 131 publications receiving 10656 citations. Previous affiliations of Benoit Chabot include Memorial Sloan Kettering Cancer Center & Faculté de médecine – Université de Sherbrooke.
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Journal ArticleDOI
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus.
TL;DR: Observations provide the first example of a germ-line mutation in a mammalian proto-oncogene and implicate the c-kit gene as a candidate for the W locus and provide a molecular entry into this important region of the mouse genome.
Journal ArticleDOI
Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.
TL;DR: It is demonstrated that the c-kit associated tyrosine-specific protein kinase is functionally impaired in W/WV mast cells, thus providing a molecular basis for understanding the developmental defects that result from mutations at the W locus.
Journal ArticleDOI
U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing
TL;DR: Use of anti-(U2)RNP autoantibodies demonstrates that U2 snRNPs associate with the precursor RNA during in vitro splicing and possible interactions of the U2snRNP with the U1 snRNP and with the pre-mRNA during splicing are considered.
Journal ArticleDOI
Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme
Célia Jeronimo,Diane Forget,Annie Bouchard,Qintong Li,Gordon Chua,Christian Poitras,Cynthia Thérien,Dominique Bergeron,Sylvie Bourassa,Jack Greenblatt,Benoit Chabot,Guy G. Poirier,Timothy P. Hughes,Mathieu Blanchette,David H. Price,Benoit Coulombe +15 more
TL;DR: A survey of soluble human protein complexes containing components of the transcription and RNA processing machineries using protein affinity purification coupled to mass spectrometry defines a high-density protein interaction network for the mammalian transcription machinery and uncover multiple regulatory factors that target the transcription machinery.
Book ChapterDOI
hnRNP proteins and splicing control.
Rebeca D. Martínez-Contreras,Philippe Cloutier,Lulzim Shkreta,Jean-François Fisette,Timothée Revil,Benoit Chabot +5 more
TL;DR: Recent advances supporting a role for heterogeneous nuclear RNP proteins in precursor-messenger RNA (pre-mRNA) splicing are discussed.