B
Benoît Moreau
Researcher at Boehringer Ingelheim
Publications - 35
Citations - 712
Benoît Moreau is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Cyclopropanation & Cancer. The author has an hindex of 11, co-authored 35 publications receiving 644 citations. Previous affiliations of Benoît Moreau include Harvard University & Université de Montréal.
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Journal ArticleDOI
Iron-Catalyzed 1,4-Hydroboration of 1,3-Dienes
TL;DR: A chemo-, regio-, and stereoselective iron-catalyzed 1,4-hydroboration of dienes that affords gamma-disubstituted allylboranes has been developed.
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Expedient synthesis of cyclopropane alpha-amino acids by the catalytic asymmetric cyclopropanation of alkenes using iodonium ylides derived from methyl nitroacetate.
Benoît Moreau,André B. Charette +1 more
TL;DR: 1-Nitrocyclopropyl esters are versatile building blocks to access the corresponding cyclopropane amino esters and aminocyclopropanes in two and three steps, respectively, from commercially available products.
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Iron-Catalyzed 1,4-Addition of α-Olefins to Dienes
TL;DR: A new intermolecular, stereo- and regioselective iron-catalyzed 1,4-addition of alpha-olefins to 1,3-dienes using as low as 1 mol % of an iminopyridine-ferrous chloride complex was developed, and both double bonds of the linear 1, 4-diene addition products are obtained with absolute stereocontrol.
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Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo.
Brian H. White,Kerry Whalen,Kristina Kriksciukaite,Rossitza G. Alargova,Tsun Au Yeung,Patrick Rosaire Bazinet,Adam Brockman,Michelle DuPont,Haley Oller,Charles-Andre Lemelin,Patrick Lim Soo,Benoît Moreau,Samantha Perino,James M. Quinn,Gitanjali Sharma,Rajesh Shinde,Beata Sweryda-Krawiec,Richard Wooster,Mark T. Bilodeau +18 more
TL;DR: PEN-221, a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate, demonstrates in vitro activity which is both potent and receptor-dependent and shifts 90-fold upon receptor blockade.
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Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution
Benoît Moreau,Jeff A. O'Meara,Josée Bordeleau,Michel Garneau,Cédrickx Godbout,Vida Gorys,Mélissa Leblanc,Elisia Villemure,Peter W. White,Montse Llinas-Brunet +9 more
TL;DR: SAR investigation and ADME/PK optimization leading to the identification of inhibitors with significantly improved potency against the key resistant variants and with increased liver partitioning are disclosed.