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Bernadette Basilico
Researcher at Institute of Science and Technology Austria
Publications - 5
Citations - 44
Bernadette Basilico is an academic researcher from Institute of Science and Technology Austria. The author has contributed to research in topics: Cell migration & Haploinsufficiency. The author has an hindex of 1, co-authored 5 publications receiving 11 citations.
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Journal ArticleDOI
Molecular mechanisms for targeted ASD treatments.
TL;DR: Molecular pathways emerging as commonly affected by mutations in diverse ASD-risk genes are focused on, on their role during critical windows of brain development and the potential treatments targeting these biological processes.
Posted ContentDOI
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
Jasmin Morandell,Lena A. Schwarz,Bernadette Basilico,Saren Tasciyan,Armel Nicolas,Christoph Sommer,Caroline Kreuzinger,Christoph P. Dotter,Lisa S. Knaus,Zoe Dobler,Emanuele Cacci,Johann G. Danzl,Gaia Novarino +12 more
TL;DR: The data indicate that Cul3 has a critical role in the regulation of cytoskeletal proteins and neuronal migration and that ASD-associated defects and behavioral abnormalities are primarily due to Cul3 functions at early developmental stages.
Journal ArticleDOI
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development.
Jasmin Morandell,Lena A. Schwarz,Bernadette Basilico,Saren Tasciyan,Georgi Dimchev,Armel Nicolas,Christoph Sommer,Caroline Kreuzinger,Christoph P. Dotter,Lisa S. Knaus,Zoe Dobler,Emanuele Cacci,Florian K. M. Schur,Johann G. Danzl,Gaia Novarino +14 more
TL;DR: In this article, the authors show that Cul3 is essential to regulate neuronal migration by tightly regulating Plastin3 (Pls3), a previously unrecognized player of neural migration.
Posted ContentDOI
Microglia control glutamatergic synapses in the adult mouse hippocampus
Bernadette Basilico,Laura Ferrucci,P. Ratano,M.T. Golia,Alfonso Grimaldi,Maria Rosito,Valentina Ferretti,Ingrid Reverte,Maria Cristina Marrone,Maria Giubettini,V. de Turris,Debora Salerno,Stefano Garofalo,Marie-Kim St-Pierre,Micaël Carrier,Massimiliano Renzi,Francesca Pagani,Marcello Raspa,Ferdinando Scavizzi,Cornelius Gross,Silvia Marinelli,Marie-Ève Tremblay,Marie-Ève Tremblay,Daniele Caprioli,Laura Maggi,Cristina Limatola,Cristina Limatola,S. Di Angelantonio,S. Di Angelantonio,Davide Ragozzino +29 more
TL;DR: In this paper, the effects of pharmacological depletion of microglia, achieved by administration of PLX5622, on hippocampal CA3-CA1 synapses of adult mice were characterized.
Journal ArticleDOI
Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration During a Critical Window of Brain Development
Jasmin Morandell,Lena A. Schwarz,Bernadette Basilico,Saren Tasciyan,Georgi Dimchev,Armel Nicolas,Christoph Sommer,Caroline Kreuzinger,Christoph P. Dotter,Lisa S. Knaus,Zoe Dobler,Emanuele Cacci,Florian K. M. Schur,Johann G. Danzl,Gaia Novarino +14 more
TL;DR: In this paper, the authors used Cul3 mouse models to evaluate the consequences of Cul3 mutations in vivo, and showed that Cul3 haploinsufficient mice exhibit deficits in motor coordination as well as ASD-relevant social and cognitive impairments.