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Bernadette Ferraro
Researcher at University of Pennsylvania
Publications - 17
Citations - 865
Bernadette Ferraro is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: DNA vaccination & Immune system. The author has an hindex of 13, co-authored 17 publications receiving 802 citations. Previous affiliations of Bernadette Ferraro include Wistar Institute.
Papers
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Journal ArticleDOI
Clinical Applications of DNA Vaccines: Current Progress
Bernadette Ferraro,Matthew P. Morrow,Natalie A. Hutnick,Thomas H. Shin,Colleen E. Lucke,David B. Weiner +5 more
TL;DR: The ability of the current, or second-generation, DNA vaccines to induce more-potent cellular and humoral responses opens up this platform to be examined in both preventative and therapeutic arenas.
Journal ArticleDOI
A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates.
Karthik Mallilankaraman,Devon J. Shedlock,Huihui Bao,Omkar U. Kawalekar,Paolo Fagone,Aarthi A. Ramanathan,Bernadette Ferraro,Jennifer Stabenow,Paluru Vijayachari,Senthil G. Sundaram,N. Muruganandam,Gopalsamy Sarangan,Padma Srikanth,Amir S. Khan,Mark G. Lewis,J. Joseph Kim,Niranjan Y. Sardesai,Karuppiah Muthumani,David B. Weiner +18 more
TL;DR: A synthetic DNA vaccine delivered by in vivo electroporation that expresses a component of the CHIKV envelope glycoprotein and used this model to evaluate its efficacy was constructed and induced robust antigen-specific cellular and humoral immune responses, which individually were capable of providing protection against Chikungunya virus challenge in mice.
Patent
Consensus Prostate Antigens, Nucleic Acid Molecule Encoding The Same And Vaccine And Uses Comprising The Same
TL;DR: In this article, consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA, are provided.
Journal ArticleDOI
Inducing Humoral and Cellular Responses to Multiple Sporozoite and Liver-Stage Malaria Antigens Using Exogenous Plasmid DNA
Bernadette Ferraro,Kendra T. Talbott,A. Balakrishnan,Neil J. Cisper,Matthrew P. Morrow,Natalie A. Hutnick,Devin J.F. Myles,Devon J. Shedlock,Nyamekye Obeng-Adjei,Jian Yan,A. K. K. Kayatani,N. Richie,W. Cabrera,R. Shiver,Amir S. Khan,Ami Shah Brown,M. Yang,U. Wille-Reece,A. J. Birkett,Niranjan Y. Sardesai,David B. Weiner +20 more
TL;DR: The data demonstrate that delivery of gene sequences by DNA/EP encoding malaria parasite antigens is immunogenic in animal models and can harness both the humoral and cellular arms of the immune system.
Journal ArticleDOI
Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques
Matthew P. Morrow,Jian Yan,Panyupa Pankhong,Bernadette Ferraro,Mark G. Lewis,Amir S. Khan,Niranjan Y. Sardesai,David B. Weiner +7 more
TL;DR: Data is presented that suggests that adjuvants differ in their relative abilities to bolster and skew immune responses in the short term compared with more distant time points, and that the scientific and medical communities would benefit from a more detailed analysis of adjuvant function.