O
Omkar U. Kawalekar
Researcher at University of Pennsylvania
Publications - 23
Citations - 4064
Omkar U. Kawalekar is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: T cell & Chimeric antigen receptor. The author has an hindex of 15, co-authored 22 publications receiving 2900 citations. Previous affiliations of Omkar U. Kawalekar include Birla Institute of Technology, Mesra & June.
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Journal ArticleDOI
CAR T cell immunotherapy for human cancer
TL;DR: Opportunities and challenges for entering mainstream oncology that presently face the CAR T field are described, with a focus on the challenges that have emerged over the past several years.
Journal ArticleDOI
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
Omkar U. Kawalekar,Roddy S. O’Connor,Joseph A. Fraietta,Lili Guo,Shannon E. McGettigan,Avery D. Posey,Prachi R. Patel,Sonia Guedan,John Scholler,Brian Keith,Nathaniel W. Snyder,Nathaniel W. Snyder,Ian A. Blair,Michael C. Milone,Carl H. June +14 more
TL;DR: The influence of signaling domains of coreceptors CD28 and 4-1BB on the metabolic characteristics of human CAR T cells is reported to provide a mechanistic insight into the differential persistence of CAR-T cells expressing 4- 1BB or CD28 signaling domains in clinical trials and inform the design of future CAR T cell therapies.
Journal ArticleDOI
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Sonia Guedan,Avery D. Posey,Carolyn E. Shaw,Anna Wing,Tong Da,Prachi R. Patel,Shannon E. McGettigan,Victoria Casado-Medrano,Omkar U. Kawalekar,Mireia Uribe-Herranz,Decheng Song,J. Joseph Melenhorst,Simon F. Lacey,John Scholler,Brian Keith,Regina M. Young,Carl H. June +16 more
TL;DR: CARs with ICOS and 4-1BB ICD demonstrate increased efficacy in solid tumor models over the current 4- 1BB-based CAR and are promising therapeutics for clinical testing.
Journal ArticleDOI
Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells
Matthew J. Frigault,Jihyun Lee,Maria C. Basil,Carmine Carpenito,Shinichiro Motohashi,John Scholler,Omkar U. Kawalekar,Sonia Guedan,Shannon E. McGettigan,Avery D. Posey,Sonny Ang,Laurence J.N. Cooper,Jesse M. Platt,F. Brad Johnson,Chrystal M. Paulos,Yangbing Zhao,Michael Kalos,Michael C. Milone,Carl H. June +18 more
TL;DR: It is reported that certain CARs endow T cells with the ability to undergo long-term autonomous proliferation and the design of CARs that have a nonconstitutive growth phenotype may be a strategy to improve efficacy and engraftment of CAR T cells.
Journal ArticleDOI
Chikungunya: A Potentially Emerging Epidemic?
Michelle Thiboutot,S. Kannan,Omkar U. Kawalekar,Devon J. Shedlock,Amir S. Khan,Gopalsamy Sarangan,Padma Srikanth,David B. Weiner,Karuppiah Muthumani +8 more
TL;DR: With the threat of an emerging global pandemic, the peculiar problems associated with the more immediate and seasonal epidemics warrant the development of an effective vaccine, and the evidence supporting these concepts is summarized.