J
Jian Yan
Researcher at Wistar Institute
Publications - 138
Citations - 5067
Jian Yan is an academic researcher from Wistar Institute. The author has contributed to research in topics: DNA vaccination & Immune system. The author has an hindex of 36, co-authored 127 publications receiving 4385 citations. Previous affiliations of Jian Yan include University of Pennsylvania.
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Journal ArticleDOI
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial.
Cornelia L. Trimble,Matthew P. Morrow,Kimberly A. Kraynyak,Xuefei Shen,Michael J. Dallas,Jian Yan,Lance Edwards,R. Lamar Parker,Lynette Denny,Mary Giffear,Ami Shah Brown,Kathleen Marcozzi-Pierce,Divya Shah,Anna M. Slager,Albert J Sylvester,Akram Khan,Kate E. Broderick,Robert J Juba,Timothy A. Herring,Jean D. Boyer,Jessica Lee,Niranjan Y. Sardesai,David B. Weiner,Mark L. Bagarazzi +23 more
TL;DR: VGX-3100 is the first therapeutic vaccine to show efficacy against CIN2/3 associated with HPV-16 and HPV-18, and could present a non-surgical therapeutic option for CIN 2/3, changing the treatment outlook for this common disease.
Journal ArticleDOI
Immunogenicity of a DNA vaccine candidate for COVID-19.
Trevor R.F. Smith,Ami Patel,Stephanie Ramos,Dustin Elwood,Xizhou Zhu,Jian Yan,Ebony N. Gary,Susanne Walker,Katherine Schultheis,Mansi Purwar,Ziyang Xu,Jewell Walters,Pratik Bhojnagarwala,Maria Yang,Neethu Chokkalingam,Patrick Pezzoli,Elizabeth Parzych,Emma L. Reuschel,Arthur Doan,Nicholas J. Tursi,Miguel Vasquez,Jihae Choi,Edgar Tello-Ruiz,Igor Maricic,Mamadou A. Bah,Yuanhan Wu,Dinah Amante,Daniel H. Park,Yaya Dia,Ali Raza Ali,Faraz I. Zaidi,Alison Generotti,Kevin Kim,Timothy A. Herring,Sophia M. Reeder,Viviane M Andrade,Karen R. Buttigieg,Gan Zhao,Jiun Ming Wu,Dan Li,Linlin Bao,Jiangning Liu,Wei Deng,Chuan Qin,Ami Shah Brown,Makan Khoshnejad,Nianshuang Wang,Jacqueline Chu,Daniel Wrapp,Jason S. McLellan,Karuppiah Muthumani,Bin Wang,Miles W. Carroll,J. Joseph Kim,Jean D. Boyer,Daniel W. Kulp,Laurent Humeau,David B. Weiner,Kate E. Broderick +58 more
TL;DR: An optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen is generated, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea pigs, and these initial results support further development of this vaccine candidate.
Journal ArticleDOI
Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses
Mark L. Bagarazzi,Jian Yan,Matthew P. Morrow,Xuefei Shen,R. Lamar Parker,Jessica Lee,Mary Giffear,Panyupa Pankhong,Amir S. Khan,Kate E. Broderick,Christine L Knott,Feng Lin,Jean D. Boyer,Ruxandra Draghia-Akli,C. Jo White,J. Joseph Kim,David B. Weiner,Niranjan Y. Sardesai +17 more
TL;DR: Encouraging phase 1 safety, tolerability, and immunogenicity results are reported for a therapeutic HPV16/18 candidate vaccine, VGX-3100, delivered by in vivo electroporation (EP), which is capable of driving robust immune responses to antigens from high-risk HPV serotypes.
Journal ArticleDOI
Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery
Spyros A. Kalams,Scott D. Parker,Marnie Elizaga,Barbara Metch,Srilatha Edupuganti,John Hural,Stephen C. De Rosa,Donald K. Carter,Kyle Rybczyk,Ian Frank,Jonathan D. Fuchs,Beryl A. Koblin,Denny H. Kim,Patrice Joseph,Michael C. Keefer,Lindsey R. Baden,John H. Eldridge,Jean D. Boyer,Adam Sherwat,Massimo Cardinali,Mary Allen,Michael Pensiero,Christopher C Butler,Amir S. Khan,Jian Yan,Niranjan Y. Sardesai,James G. Kublin,David B. Weiner +27 more
TL;DR: This study illustrates the power of combined DNA approaches to generate impressive immune responses in humans by using electroporation after PV administration to provide immunogenicity superior to that observed in the trial without Electroporation, despite fewer vaccinations.
Journal ArticleDOI
Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens
Dominick Laddy,Jian Yan,Michele A. Kutzler,Darwyn Kobasa,Gary P. Kobinger,Gary P. Kobinger,Amir S. Khan,Jack Greenhouse,Niranjan Y. Sardesai,Ruxandra Draghia-Akli,David B. Weiner +10 more
TL;DR: The ability of these antigens to protect from both morbidity and mortality in a ferret model of HPAI, in both the presence and absence of neutralizing antibody, will be critical in responding to the antigenic drift that will likely occur before these viruses cross the species barrier to humans.