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Paolo Fagone
Researcher at University of Catania
Publications - 123
Citations - 5231
Paolo Fagone is an academic researcher from University of Catania. The author has contributed to research in topics: Immune system & Macrophage migration inhibitory factor. The author has an hindex of 33, co-authored 112 publications receiving 4355 citations. Previous affiliations of Paolo Fagone include University of Pennsylvania.
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Journal ArticleDOI
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Linda S. Steelman,William H. Chappell,Stephen L. Abrams,C. Ruth Kempf,Jacquelyn M. Long,Piotr Laidler,Sanja Mijatović,Danijela Maksimović-Ivanić,Franca Stivala,Maria Clorinda Mazzarino,Marco Donia,Paolo Fagone,Graziella Malaponte,Ferdinando Nicoletti,Massimo Libra,Michele Milella,Agostino Tafuri,Antonio Bonati,Jörg Bäsecke,Lucio Cocco,Camilla Evangelisti,Alberto M. Martelli,Giuseppe Montalto,Melchiorre Cervello,James A. McCubrey +24 more
TL;DR: The functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli are discussed and the recently described roles of these pathways in cancer stem cells, cellular senescence and aging are evaluated.
Journal ArticleDOI
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
William H. Chappell,Linda S. Steelman,Jacquelyn M. Long,Ruth C. Kempf,Stephen L. Abrams,Richard A. Franklin,Jörg Bäsecke,Franca Stivala,Marco Donia,Paolo Fagone,Graziella Malaponte,Maria Clorinda Mazzarino,Ferdinando Nicoletti,Massimo Libra,Danijela Maksimović-Ivanić,Sanja Mijatović,Giuseppe Montalto,Melchiorre Cervello,Piotr Laidler,Michele Milella,Agostino Tafuri,Antonio Bonati,Camilla Evangelisti,Lucio Cocco,Alberto M. Martelli,James A. McCubrey +25 more
TL;DR: This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging.
Journal ArticleDOI
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
James A. McCubrey,Linda S. Steelman,William H. Chappell,Stephen L. Abrams,Richard A. Franklin,Giuseppe Montalto,Melchiorre Cervello,Massimo Libra,Saverio Candido,Grazia Malaponte,Maria Clorinda Mazzarino,Paolo Fagone,Ferdinando Nicoletti,Jörg Bäsecke,Sanja Mijatović,Danijela Maksimović-Ivanić,Michele Milella,Agostino Tafuri,Francesca Chiarini,Camilla Evangelisti,Lucio Cocco,Alberto M. Martelli +21 more
TL;DR: How cancers can become insensitive to various inhibitors and potential strategies to overcome this resistance are discussed.
Journal ArticleDOI
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response
James A. McCubrey,Linda S. Steelman,William H. Chappell,Stephen L. Abrams,Giuseppe Montalto,Melchiorre Cervello,Ferdinando Nicoletti,Paolo Fagone,Grazia Malaponte,Maria Clorinda Mazzarino,Saverio Candido,Massimo Libra,Jörg Bäsecke,Sanja Mijatović,Danijela Maksimović-Ivanić,Michele Milella,Agostino Tafuri,Lucio Cocco,Camilla Evangelisti,Francesca Chiarini,Alberto M. Martelli +20 more
TL;DR: The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are described and how genetic mutations and epigenetic alterations can result in resistance to various inhibitors are discussed.
Journal ArticleDOI
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Linda S. Steelman,Richard A. Franklin,Steve L. Abrams,William H. Chappell,C. R. Kempf,Jörg Bäsecke,Franca Stivala,Marco Donia,Paolo Fagone,Ferdinando Nicoletti,Massimo Libra,Peter P. Ruvolo,Vivian Ruvolo,Camilla Evangelisti,Am Martelli,James A. McCubrey +15 more
TL;DR: In this article, the authors discuss the mechanisms by which abnormal expression of the Ras/Raf/MEK/ERK pathway can contribute to drug resistance as well as resistance to targeted leukemia therapy.