Bernard Hainque

TL;DR: A systematic screening of 9 genes in a large population to evaluate the distribution of the disease genes, and to determine the best molecular strategy in clinical practice, found that screening of already known mutations is not helpful and several mutations should be searched.

TL;DR: Results suggest that, as for leptin, circulating IL-6 concentrations reflect, at least in part, adipose tissue production reduced after weight loss, and could play a role in the improved sensitivity to insulin observed in these patients.

TL;DR: Increased IL-6 production by sc adipose cells might participate to the insulin-resistant state observed in human obesity, suggesting that locally secreted IL- 6 could act on adipocytes by an autocrine/paracrine mechanism.

TL;DR: Animal models and in vitro analyses have allowed a better understanding of the pathophysiological mechanisms associated with familial hypertrophic cardiomyopathy, and the development of other animal models and of other mechanistic studies linking the genetic mutation to functional defects are now key issues in understanding how alterations in the basic contractile unit of theCardiomyocyte alter the phenotype and the function of the heart.

TL;DR: The results indicate a strong relationship between adipocytokines and inflammatory markers, and suggest that cytokines secreted by adipose tissue in obese subjects could play a role in increased inflammatory proteins secretion by the liver.