C
Claude Jardel
Researcher at French Institute of Health and Medical Research
Publications - 102
Citations - 6361
Claude Jardel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 39, co-authored 101 publications receiving 5779 citations. Previous affiliations of Claude Jardel include Paris Descartes University & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss.
Jean-Philippe Bastard,Claude Jardel,Eric Bruckert,Patricia Blondy,Jacqueline Capeau,Martine Laville,Hubert Vidal,Bernard Hainque +7 more
TL;DR: Results suggest that, as for leptin, circulating IL-6 concentrations reflect, at least in part, adipose tissue production reduced after weight loss, and could play a role in the improved sensitivity to insulin observed in these patients.
Journal ArticleDOI
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
Jean-Philippe Bastard,Mustapha Maachi,Jeanne Tran Van Nhieu,Claude Jardel,Eric Bruckert,André Grimaldi,Jean-Jacques Robert,Jacqueline Capeau,Bernard Hainque +8 more
TL;DR: Increased IL-6 production by sc adipose cells might participate to the insulin-resistant state observed in human obesity, suggesting that locally secreted IL- 6 could act on adipocytes by an autocrine/paracrine mechanism.
Journal ArticleDOI
Genetic diagnosis of Mendelian disorders via RNA sequencing
Laura S. Kremer,Daniel M. Bader,Daniel M. Bader,Christian Mertes,Robert Kopajtich,Garwin Pichler,Arcangela Iuso,Tobias B. Haack,Tobias B. Haack,Elisabeth Graf,Thomas Schwarzmayr,Caterina Terrile,Eliska Konafikova,Birgit Repp,Gabi Kastenmüller,Jerzy Adamski,Peter Lichtner,Christoph Leonhardt,Benoît Funalot,Alice Donati,Valeria Tiranti,Anne Lombès,Anne Lombès,Anne Lombès,Claude Jardel,Dieter Gläser,Robert W. Taylor,Daniele Ghezzi,Johannes A. Mayr,Agnès Rötig,Peter Freisinger,Felix Distelmaier,Tim M. Strom,Thomas Meitinger,Julien Gagneur,Julien Gagneur,Holger Prokisch +36 more
TL;DR: The power of transcriptome sequencing is demonstrated to molecularly diagnose 10% of mitochondriopathy patients and identify candidate genes for the remainder, and examples of intronic loss-of-function variants with pathological relevance are provided.
Journal ArticleDOI
Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women.
Maachi M,L Piéroni,Eric Bruckert,Claude Jardel,S. Fellahi,Bernard Hainque,Jacqueline Capeau,Jean-Philippe Bastard +7 more
TL;DR: The results indicate a strong relationship between adipocytokines and inflammatory markers, and suggest that cytokines secreted by adipose tissue in obese subjects could play a role in increased inflammatory proteins secretion by the liver.
Journal ArticleDOI
CSF biomarker variability in the Alzheimer's Association quality control program
Niklas Mattsson,Niklas Mattsson,Ulf Andreasson,Staffan Persson,Maria C. Carrillo,Steven J. Collins,Sonia Chalbot,Neal Cutler,Diane Dufour-Rainfray,Anne M. Fagan,Niels H. H. Heegaard,Ging-Yuek Robin Hsiung,Bradley T. Hyman,Khalid Iqbal,D. Richard Lachno,Alberto Lleó,Piotr Lewczuk,José Luis Molinuevo,Piero Parchi,Axel Regeniter,Robert A. Rissman,Hanna Rosenmann,Giuseppe Sancesario,Johannes Schröder,Leslie M. Shaw,Charlotte E. Teunissen,John Q. Trojanowski,Hugo Vanderstichele,Manu Vandijck,Marcel M. Verbeek,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Stephan A. Käser,Aladro José A. Rojo,Marilyn S. Albert,Daniel Alcolea,Anna Antonell,Hiroyuki Arai,Silvana Archetti,Eva Arkblad,Inês Baldeiras,Ales Bartos,Dev Batish,Aurélie Bedel,Daniele Bentue-Ferrer,Flora Berisha,Sergio Bernardini,Marinus A. Blankenstein,Olivier Bousiges,Michael C. Camuso,Maria Berrocal Carrillo,Tiziana Casoli,Sebastiano Cavallaro,Odete A. da Cruz e Silva,Isabelle Cuvelier,Odile Delaroche,Roy B. Dyer,Sebastiaan Engelborghs,Anne Fogli,Orestes Vicente Forlenza,Nick C. Fox,Giovanni B. Frisoni,Daniela Galimberti,Elisabetta Galloni,Silvana Gritti,Karen H. Gylys,Harald Hampel,Sabine Haustein,Theresa Heath,Michael T. Heneka,Sanna-Kaisa Herukka,David M. Holtzman,Christian Humpel,Takeshi Iwatsubo,Claude Jardel,Mathias Jucker,Elisabeth Kapaki,Daniel Kidd,Péter Klivényi,Ryozo Kuwano,Foudil Lamari,Jean-Louis Laplanche,Jordan Laser,Sylvian Lehmann,Qiao-Xin Li,Walter Maetzler,Catherine Malaplate-Armand,Ralph Martin,Robert Martone,Colin L. Masters,Marc Mercken,Jose Luis Molinuevo,T. J. Montine,William Nowatzke,Markus Otto,Xavier Parent,Lucilla Parnetti,Ronald C. Petersen,Koen Poesen,Isabelle Quadrio,Muriel Quillard,Vara Luis Rello,Zdenek Rohan,Christin Sisowath,Anders Skinningsrud,Holly Soares,Hilkka Soininen,Knudsen Cindy Søndersø,Annette Spreer,Silvia Suardi,C.E. Teunissen,Robert M. Umek,Bianca Van Broeck,Rik Vandenberghe,László Vécsei,M.M. Verbeek,Igor Vostiar,Manfred Windisch +118 more
TL;DR: The cerebrospinal fluid biomarkers amyloid beta 1–42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease research and patient management, but there are large variations in biomarker measurements among and within laboratories.