Bernard T. Golding

TL;DR: A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6, 7- and 8-aryl-substituted chromenone libraries, which were screened as inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK) and resulted in the identification of 8-dibenzothiophen-4-yl-2-morpholin-4,yl-chromen-4 one as a highly potent and selective DNA-PK inhibitor.

TL;DR: The preclinical development of 2-aryl-1H-benzimidazole-4-carboxamides as resistance-modifying agents in cancer chemotherapy is described, and important hydrogen-bonding and hydrophobic interactions with the protein have been identified for this inhibitor.

TL;DR: Investigations funded by the Deutsche Forschungsgemeinschaft on the anaerobic microbial degradation of hydrocarbons ranged from isolation and enrichment of hitherto unknown hydrocarbon-degrading anaerobe microorganisms, discovery of novel reactions, detailed studies of enzyme mechanisms and structures to process-oriented in situ studies.

TL;DR: The hypothesis that increased hydrocarbon exposure results in an altered sediment microbial community structure that reflects the prospects for oil biodegradation under the prevailing conditions is examined and increased exposure to hydrocarbons enriches Deltaproteobacteria, which are known to be capable of anaerobic hydrocarbon metabolism.

TL;DR: Two radical enzymes are discussed, pyruvate:ferredoxin oxidoreductase and methane-forming methyl-CoM reductase, which catalyze their main reaction in two-electron steps, but subsequent electron transfers proceed via radicals.