Bert Luck

TL;DR: The deletion of CSE from endothelial cells was associated with the accelerated development of endothelial dysfunction and atherosclerosis, effects that were reversed on treatment with a polysulfide donor.

TL;DR: This work describes a LC-MS/MS-based method that makes use of Sulfane Sulfur Probe 4 to detect endogenously generated polysulfides in biological samples in a selective, sensitive and quantitative manner and indicates a large variability in the activity of the H2S-generating enzymes in different murine organs.

TL;DR: The cytochrome P450 system accounts for the majority of the signal of Nox activity chemiluminescence based assays, and membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH‐dependent signal with lucigenin which was abolished by the knockout of POR but not by knockout of p22phox.

TL;DR: It is reported that active endothelial NO synthase (eNOS) interacts with and S‐nitrosates pyruvate kinase M2 (PKM2), which reduces PKM2 activity, and eNOS inhibition increases substrate flux through the pentose phosphate pathway to generate reducing equivalents and protect against oxidative stress.

TL;DR: In this paper , the authors present a data sharing initiative to provide a common framework to contextualize and estimate the risk posed by presence of nitrites to contribute to the formation of nitrosamines in drug products.