Berta Segura-Collar

TL;DR: The transcription of microtubule-associated protein TAU (MAPT), a gene that has been classically associated with neurodegenerative diseases, is epigenetically controlled by the balance between wt and mut IDH1/2 in mouse and human gliomas.

TL;DR: The new genetic and epigenetic classification of gliomas and the description of the different transcriptional subtypes are revised and the interaction of the plastic tumor cells with their vasculature-rich microenvironment and with their distinct immune system is focused on.

TL;DR: The main knowledge about Tau function and expression in tumors is reviewed, with a special focus on brain cancer, and its function in cancer has not yet been addressed.

TL;DR: It is suggested that glioma growth depends on modifications of the vesicle transport system, reliant on kish/TMEM167A, which could be a key for future therapeutic strategies targeting EGFR‐dependent gliomas.

TL;DR: In this paper, the authors identify the EGFR-related mechanisms that govern the capacity of glioma cells to transdifferentiate into pericytes, regulating the vascular and immune phenotypes of the tumors.