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Betsaida Bibo-Verdugo
Researcher at Discovery Institute
Publications - 11
Citations - 217
Betsaida Bibo-Verdugo is an academic researcher from Discovery Institute. The author has contributed to research in topics: Proteasome & Pyroptosis. The author has an hindex of 6, co-authored 9 publications receiving 136 citations. Previous affiliations of Betsaida Bibo-Verdugo include Spanish National Research Council & University of California, San Diego.
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Journal ArticleDOI
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
Gregory LaMonte,Jehad Almaliti,Jehad Almaliti,Betsaida Bibo-Verdugo,Lena Keller,Bing Yu Zou,Jennifer H. Yang,Yevgeniya Antonova-Koch,Pamela Orjuela-Sánchez,Colleen A. Boyle,Edgar Vigil,Lawrence Wang,Gregory M. Goldgof,Lena Gerwick,Anthony J. O’Donoghue,Elizabeth A. Winzeler,William H. Gerwick,Sabine Ottilie +17 more
TL;DR: This study synthesized a series of chemical analogs that reduce host cell toxicity while maintaining blood-stage and gametocytocidal antimalarial activity and proteasome inhibition, and describes a promising new class of antimalaria compound based on the carmaphycin B scaffold.
Journal ArticleDOI
Targeting proteasomes in infectious organisms to combat disease.
Betsaida Bibo-Verdugo,Betsaida Bibo-Verdugo,Zhenze Jiang,Zhenze Jiang,Conor R. Caffrey,Conor R. Caffrey,Anthony J. O’Donoghue,Anthony J. O’Donoghue +7 more
TL;DR: Efforts to validate the proteasome in pathogenic organisms as a therapeutic target are summarized and several strategies that have been used to develop inhibitors with increased potency and selectivity for the pathogen prote as well as anti‐infective agents are described.
Journal ArticleDOI
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11
TL;DR: It is proposed that P1′–P4′-based inhibitors could be exploited to specifically target inflammatory caspases and confirmed that the substrate specificities of the human orthologs of caspase-11 are ruled by the same mechanism.
Journal ArticleDOI
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.
Betsaida Bibo-Verdugo,Betsaida Bibo-Verdugo,Betsaida Bibo-Verdugo,Steven C Wang,Steven C Wang,Jehad Almaliti,Jehad Almaliti,Anh P. Ta,Zhenze Jiang,Zhenze Jiang,Derek A. Wong,Christopher B. Lietz,Brian M. Suzuki,Brian M. Suzuki,Nelly El-Sakkary,Nelly El-Sakkary,Vivian Hook,Guy S. Salvesen,William H. Gerwick,William H. Gerwick,Conor R. Caffrey,Conor R. Caffrey,Anthony J. O’Donoghue,Anthony J. O’Donoghue +23 more
TL;DR: Direct evidence of the proteasome's importance to schistosome viability is provided and a lead is identified for which future studies will aim to improve the potency, selectivity and safety.
Journal ArticleDOI
A chymotrypsin from the Digestive Tract of California Spiny Lobster, Panulirus interruptus: Purification and Biochemical Characterization
Betsaida Bibo-Verdugo,Liliana Rojo-Arreola,Marı́a de los A. Navarrete-del-Toro,Fernando García-Carreño +3 more
TL;DR: A chymotrypsin was purified from the gastric juice of California spiny lobster, using preparative electrophoresis and affinity chromatography on agarose-p-aminobenzamidine, andeduced amino acid sequence, corroborated by mass spectrometry, was determined.