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Betty Y.L. Wong
Researcher at Sunnybrook Health Sciences Centre
Publications - 35
Citations - 2411
Betty Y.L. Wong is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Vitamin D and neurology & Vitamin D-binding protein. The author has an hindex of 20, co-authored 34 publications receiving 2282 citations. Previous affiliations of Betty Y.L. Wong include University of Toronto & Toronto General Hospital.
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Journal ArticleDOI
Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer
Harvey A. Risch,John R. McLaughlin,David E. C. Cole,Barry P. Rosen,Linda A. Bradley,Elaine Kwan,Elaine Jack,Danny Vesprini,Graciela Kuperstein,John L.A. Abrahamson,Isabel Fan,Betty Y.L. Wong,Steven A. Narod +12 more
TL;DR: Risks of ovarian, breast, and stomach cancers and leukemias/lymphomas were increased nine-, five-, six- and threefold, respectively, among first-degree relatives of cases carrying BRCA1 mutations, compared with relatives of noncarriers, and risk of colorectal cancer was increased threefold for relatives of Cases carrying B RCA2 mutations.
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Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.
Lei Fu,Francisco H. J. Yun,Marko Oczak,Betty Y.L. Wong,Reinhold Vieth,Reinhold Vieth,David E. C. Cole +6 more
TL;DR: As with baseline 25( OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.
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Phase II Trial Evaluating the Palliative Benefit of Second-Line Zoledronic Acid in Breast Cancer Patients With Either a Skeletal-Related Event or Progressive Bone Metastases Despite First-Line Bisphosphonate Therapy
Mark Clemons,George Dranitsaris,W. Ooi,Geetha Yogendran,Tatjana Sukovic,Betty Y.L. Wong,Sunil Verma,Kathleen I. Pritchard,Maureen E. Trudeau,David E. C. Cole +9 more
TL;DR: This is the first study to demonstrate that patients with either progressive bone metastases or SREs while on clodronate or pamidronate can have relevant palliative benefits with a switch to the more potent bisphosphonate zoledronic acid, reflected by significant improvements in pain control and bone turnover markers.
Journal ArticleDOI
Common variants of the vitamin D binding protein gene and adverse health outcomes
Suneil Malik,Lei Fu,David James Juras,Mohamed A. Karmali,Betty Y.L. Wong,Agnes Gozdzik,David E. C. Cole +6 more
TL;DR: DBP variants are a significant and common genetic factor in some common disorders, and therefore, are worthy of closer attention, according to a review of reports to date of associations between DBP variants, and various chronic and infectious diseases.
Journal ArticleDOI
Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers.
Thomas O. Carpenter,Jane H. Zhang,Esteban J. Parra,Bruce Ellis,Christine A. Simpson,William M. Lee,Jody Balko,Lei Fu,Betty Y.L. Wong,David E. C. Cole +9 more
TL;DR: Multivariate analysis revealed that genetic variance in GC significantly contributes to circulating DBP as well as 25‐OHD, and the effect of GC SNPs on 25-OHD are evident after adjusting for their effects on circulate DBP.