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Bharti Bisht
Researcher at University of California, Los Angeles
Publications - 15
Citations - 660
Bharti Bisht is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Cellular differentiation & Stem cell. The author has an hindex of 7, co-authored 13 publications receiving 442 citations.
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Journal ArticleDOI
Dynamic Changes in Intracellular ROS Levels Regulate Airway Basal Stem Cell Homeostasis through Nrf2-Dependent Notch Signaling
Manash K. Paul,Bharti Bisht,Daphne O. Darmawan,Richard Chiou,Vi Luan Ha,William D. Wallace,Andrew T. Chon,Ahmed E. Hegab,Tristan Grogan,David Elashoff,Jackelyn A. Alva-Ornelas,Brigitte N. Gomperts +11 more
TL;DR: It is shown in mouse and human airway basal stem cells (ABSCs) that intracellular flux from low to moderate ROS levels is required for stem cell self-renewal and proliferation and redox-mediated regulation of lung stem cell function.
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Novel Stem/Progenitor Cell Population from Murine Tracheal Submucosal Gland Ducts with Multipotent Regenerative Potential
Ahmed E. Hegab,Vi Luan Ha,Jennifer L. Gilbert,Kelvin Xi Zhang,Stephen P. Malkoski,Andy T. Chon,Daphne O. Darmawan,Bharti Bisht,Aik Ooi,Matteo Pellegrini,Derek W. Nickerson,Brigitte N. Gomperts +11 more
TL;DR: It is demonstrated that airway submucosal gland (SMG) duct cells, in addition to BCs, survived severe hypoxic‐ischemic injury and are therefore a multipotent stem cell for airway epithelial repair.
Journal ArticleDOI
Isolation and In Vitro Characterization of Basal and Submucosal Gland Duct Stem/Progenitor Cells from Human Proximal Airways
Ahmed E. Hegab,Vi Luan Ha,Daphne O. Darmawan,Jennifer L. Gilbert,Aik Ooi,Yasser S. Attiga,Bharti Bisht,Derek W. Nickerson,Brigitte N. Gomperts +8 more
TL;DR: It is found that only aldehyde dehydrogenase (ALDH)hi basal and duct cells were capable of sphere formation, and global inhibition of ALDH, as well as specific inhibition of the ALDH2 isoform, inhibited self‐renewal of both basal andduct cells, thereby producing fewer and smaller spheres.
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Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging.
Cody J. Aros,Preethi Vijayaraj,Carla J. Pantoja,Bharti Bisht,Luisa K. Meneses,Jenna M. Sandlin,Jonathan A. Tse,Michelle W. Chen,Arunima Purkayastha,David W Shia,Jennifer M.S. Sucre,Tammy M. Rickabaugh,Eszter K. Vladar,Manash K. Paul,Brigitte N. Gomperts +14 more
TL;DR: It is found that Wnt/β-catenin within ABSCs was essential for proliferation post-injury in vivo, and multiple spatiotemporally dynamic Wnt-secreting niches that regulate functionally distinct phases of airway regeneration and aging are underscore.
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Advances in the Fabrication of Scaffold and 3D Printing of Biomimetic Bone Graft.
TL;DR: In this article, the authors summarize the advances in scaffold fabrication techniques, emphasizing 3D printing of biomimetic bone grafts, which will be used to replace traditional bone graft substitutes such as metals, biomaterial coated metals and biodegradable scaffolds.