Bharti Bisht

TL;DR: It is shown in mouse and human airway basal stem cells (ABSCs) that intracellular flux from low to moderate ROS levels is required for stem cell self-renewal and proliferation and redox-mediated regulation of lung stem cell function.

TL;DR: It is demonstrated that airway submucosal gland (SMG) duct cells, in addition to BCs, survived severe hypoxic‐ischemic injury and are therefore a multipotent stem cell for airway epithelial repair.

TL;DR: It is found that only aldehyde dehydrogenase (ALDH)hi basal and duct cells were capable of sphere formation, and global inhibition of ALDH, as well as specific inhibition of the ALDH2 isoform, inhibited self‐renewal of both basal andduct cells, thereby producing fewer and smaller spheres.

TL;DR: It is found that Wnt/β-catenin within ABSCs was essential for proliferation post-injury in vivo, and multiple spatiotemporally dynamic Wnt-secreting niches that regulate functionally distinct phases of airway regeneration and aging are underscore.

TL;DR: In this article, the authors summarize the advances in scaffold fabrication techniques, emphasizing 3D printing of biomimetic bone grafts, which will be used to replace traditional bone graft substitutes such as metals, biomaterial coated metals and biodegradable scaffolds.